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Nanoparticles containing endocannabinoid (2-arachidonoylglycerol, 2-AG) can serve as stable, long-lasting mobilization agents for hematopoietic cells. These polycaprolactone (PCL) nanoparticles are prepared using the emulsion evaporation method, and their physicochemical properties such as particle size, polydispersity index (PDI), zeta potential, encapsulation efficiency, and release profile, are characterized. Here, we describe the preparation and characterization methods for 2-AG-loaded PCL nanoparticles.

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Preparation and Characterization of Nanoparticles for the Controlled Release of the Endocannabinoid 2-Arachidonoylglycerol (2-AG)

  • 实验方案

  • 发表日期：

    2025年

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  • Sevil Köse,
  • Cem Varan,
  • Tuba Reçber,
  • Emirhan Nemutlu,
  • Erem Bilensoy,
  • Petek Korkusuz

摘要

Nanoparticles containing endocannabinoid (2-arachidonoylglycerol, 2-AG) can serve as stable, long-lasting mobilization agents for hematopoietic cells. These polycaprolactone (PCL) nanoparticles are prepared using the emulsion evaporation method, and their physicochemical properties such as particle size, polydispersity index (PDI), zeta potential, encapsulation efficiency, and release profile, are characterized. Here, we describe the preparation and characterization methods for 2-AG-loaded PCL nanoparticles.