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The hemorrhagic fever viruses most urgently requiring therapeutic interventions include filoviruses (Ebola, Marburg), flaviviruses (e.g., dengue, yellow fever, tick-borne encephalitis), arenaviruses (e.g., Lassa fever virus, Junín virus), bunyaviruses (Rift Valley fever, Crimean-Congo hemorrhagic fever), Mammarenavirus (Lassa, Junín), and hantaviruses (Hantaan). Potential therapeutic agents under consideration include ribavirin, remdesivir, favipiravir, sofosbuvir, uprifosbuvir, galidesivir (BCX4430), UV-4B, BP34610, ARN-750-39, ARN-75041, mitoxantrone, H44, 5,6-chloro-2-phenyl-benzotriazoles, and cap-dependent endonuclease inhibitors, as well as combinations of these agents. The latter might be explored further for their potential to enhance antiviral efficacy through synergistic action.

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Therapeutic Options for Hemorrhagic Fever Virus Infections

  • 章节

  • 发表日期：

    2026年

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  • Erik De Clercq,
  • Yuya Zhang,
  • Qixiang Song,
  • Jie Huang,
  • Daniel Růžek,
  • Ricardo Khouri,
  • Guangdi Li

摘要

The hemorrhagic fever viruses most urgently requiring therapeutic interventions include filoviruses (Ebola, Marburg), flaviviruses (e.g., dengue, yellow fever, tick-borne encephalitis), arenaviruses (e.g., Lassa fever virus, Junín virus), bunyaviruses (Rift Valley fever, Crimean-Congo hemorrhagic fever), Mammarenavirus (Lassa, Junín), and hantaviruses (Hantaan). Potential therapeutic agents under consideration include ribavirin, remdesivir, favipiravir, sofosbuvir, uprifosbuvir, galidesivir (BCX4430), UV-4B, BP34610, ARN-750-39, ARN-75041, mitoxantrone, H44, 5,6-chloro-2-phenyl-benzotriazoles, and cap-dependent endonuclease inhibitors, as well as combinations of these agents. The latter might be explored further for their potential to enhance antiviral efficacy through synergistic action.