The sustainable management of wastewater and sludge is essential for addressing global water scarcity, public health, and environmental sustainability. This chapter provides an overview of existing policy frameworks for wastewater and sludge reuse, focusing on international, national, and regional regulations. It discusses key directives such as the European Union’s Urban Wastewater Treatment Directive (UWWTD), U.S. Environmental Protection Agency (EPA) guidelines, and World Health Organization (WHO) recommendations. Additionally, the chapter highlights challenges in policy implementation, technological advancements influencing regulatory frameworks, and future recommendations for improving governance and promoting circular economy principles in wastewater and sludge management.