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Lung cancer is associated with one of the highest cancer-related mortality rates and is the second most prevalent cancer worldwide. Diagnosis and treatment of lung cancer has different challenges as in most cases, and it is often diagnosed late when metastatic spread is widely disseminated. The development of chemo- and radioresistance of lung cancer, as well as a lack of specific treatment, has resulted in a very high mortality and morbidity. Noncoding RNAs (ncRNAs) are a group of RNAs with a wide spectrum of functions required for homeostasis. These RNAs modulate the expression of proteins posttranslationally and control the cell phenotype. Studies have shown that these RNAs could act as both oncogene and oncosuppressor, and due to their great therapeutic and diagnostic potential, recent studies have also focused on their use as biomarkers for early detection of cancers. Understanding the current findings in this field would help scientists to have an overview about different ncRNAs and their role in lung cancer progression. This chapter explores the landscape of ncRNA research related to lung cancer, highlighting the potential for novel diagnostic and therapeutic strategies.

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RETRACTED CHAPTER: Epigenetich Mechanisms Involved in the Etiology of Lung Cancers: From Noncoding RNAs to Exosomal Noncoding RNAs

  • 章节

  • 发表日期：

    2025年

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  • Mahdi Rafiyan,
  • Seyyede Fatemeh Mahmoudhashemi,
  • Elham Tootoonchi,
  • Majid Mousavi,
  • Ali Shafiei,
  • Niloufar Rezaei,
  • Mohammadamin Morshedi,
  • Mohammadmatin Morshedi,
  • Gordon A. Ferns,
  • Hamidreza Jamaati,
  • Seyed MohammadReza Hashemian,
  • Hamed Mirzaei

摘要

Lung cancer is associated with one of the highest cancer-related mortality rates and is the second most prevalent cancer worldwide. Diagnosis and treatment of lung cancer has different challenges as in most cases, and it is often diagnosed late when metastatic spread is widely disseminated. The development of chemo- and radioresistance of lung cancer, as well as a lack of specific treatment, has resulted in a very high mortality and morbidity. Noncoding RNAs (ncRNAs) are a group of RNAs with a wide spectrum of functions required for homeostasis. These RNAs modulate the expression of proteins posttranslationally and control the cell phenotype. Studies have shown that these RNAs could act as both oncogene and oncosuppressor, and due to their great therapeutic and diagnostic potential, recent studies have also focused on their use as biomarkers for early detection of cancers. Understanding the current findings in this field would help scientists to have an overview about different ncRNAs and their role in lung cancer progression. This chapter explores the landscape of ncRNA research related to lung cancer, highlighting the potential for novel diagnostic and therapeutic strategies.