Enzyme-polymer hybrids combine the resources provided by nature – enzymes – with a chemical toolbox – synthetic polymers – in the laboratory for carrying out complex chemical reactions with high selectivity outside of cellular machinery. Recent advances in polymer chemistry have opened new opportunities for imparting novel, adjustable functionalities into enzymes, which act as an anchoring site for precise accommodation of inorganic catalysts (nanoparticles, nanoclusters, and single atoms) and give rise to the creation of artificial multicatalytic systems. This book chapter summarizes the latest progress in designing supramolecular catalytic hybrid materials with applications in chemoenzymatic reactions. Additionally, it discusses the challenges and limitations in this field, along with potential future directions.