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The most valuable, readily available, and easy-to-use techniques to assess response to radiation therapy and chemotherapy in malignant bone tumours are anatomical MRI, dynamic contrast-enhanced MRI (DCE-MRI), diffusion-weighted MR imaging, and 18F-FDG PET-CT. Dynamic contrast-enhanced MR imaging allows to study the physiological effects of therapy graphically in time-intensity curves, time-concentration curves, or in parametric images and corresponding vascularisation parameters, which display tumour microvascularisation, perfusion, capillary permeability, bulk water flow, and volume of the interstitial space. Diffusion-weighted MRI assesses the cellularity and interstitial composition of the tumour and its microenvironment in terms of diffusion restriction. This can be performed both graphically and by analysing the apparent diffusion coefficient values and parametric maps. 18F-FDG PET-CT assesses the glucose metabolism changes during therapy. Findings indicating good response to therapy in bone sarcomas are as follows: Findings indicating poor response to therapy in bone sarcomas are as follows:

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Assessment of Response to Chemotherapy and Radiotherapy

  • 章节

  • 发表日期：

    2026年

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  • Maxime Van Sumere,
  • Thomas Van Den Berghe,
  • Koenraad Verstraete

摘要

The most valuable, readily available, and easy-to-use techniques to assess response to radiation therapy and chemotherapy in malignant bone tumours are anatomical MRI, dynamic contrast-enhanced MRI (DCE-MRI), diffusion-weighted MR imaging, and 18F-FDG PET-CT. Dynamic contrast-enhanced MR imaging allows to study the physiological effects of therapy graphically in time-intensity curves, time-concentration curves, or in parametric images and corresponding vascularisation parameters, which display tumour microvascularisation, perfusion, capillary permeability, bulk water flow, and volume of the interstitial space. Diffusion-weighted MRI assesses the cellularity and interstitial composition of the tumour and its microenvironment in terms of diffusion restriction. This can be performed both graphically and by analysing the apparent diffusion coefficient values and parametric maps. 18F-FDG PET-CT assesses the glucose metabolism changes during therapy. Findings indicating good response to therapy in bone sarcomas are as follows: Findings indicating poor response to therapy in bone sarcomas are as follows: