This concise chapter on osteonecrosis and osteochondrosis in the wrist and hand details the aetiology and typical bones involved in these conditions, and provides detailed descriptions of the available imaging modalities including plain radiograph, computed tomography, scintigraphy and magnetic resonance imaging, each with their strengths and weaknesses. Individual descriptions and classification of carpal bone osteonecrosis and osteochondrosis including Kienbock’s disease of the lunate and the rarer Preiser’s disease of the scaphoid are included.