Microbiota Genomics and Cancer: Potential Role in Prediction as Tumor Markers, Diagnosis, and Response to Treatment
摘要
Microbiome, inhabiting different parts of the body, is known to be related to the development, treatment, and progress of cancer. Certain microbes and their metabolites can either directly or indirectly contribute to the cancer pathogenesis. Moreover, there exist microbes that exert anticarcinogenic effects and inhibit cancer development. Interestingly, the latest findings indicate that the microbiome composition can modulate the metabolism of cancer immunotherapeutic agents and increase or decrease their efficacy. The microbiota is essential for host immune responses and has an intertwined association with cancer pathophysiology. In the light of microbiome-targeted therapies, patients with cancer can benefit from better quality of life and even increased survival. This chapter provides an in-depth discussion of the role of microbiota in different aspects of cancer, from development to diagnosis and treatment.