The impact of oral cancer on individuals worldwide is a grave concern. It is crucial to identify the disease early to improve treatment outcomes. However, conventional diagnostic methods can be invasive and time-consuming. Fortunately, scientists have been investigating the utilization of salivary biomarkers to diagnose oral cancers. This innovative approach provides a non-invasive, cost-effective, and convenient way to detect the disease in its initial stages. Salivary biomarkers are a collection of saliva proteins, enzymes, and nucleic acids. They offer crucial insights into the presence and advancement of oral cancers. These biomarkers are incredibly precise and can identify the disease before visible symptoms manifest. Multiple salivary biomarkers have been discovered to aid in oral cancer diagnosis. They include tumor-associated proteins, DNA mutations, and microRNAs. Employing these biomarkers alone or in combination can result in a more precise and dependable diagnosis. Numerous studies have demonstrated that salivary biomarkers possess exceptional diagnostic accuracy and distinguish between oral cancer patients and healthy individuals with remarkable sensitivity and specificity. In addition, these biomarkers can be utilized to track disease progression and treatment response, allowing healthcare providers to customize treatment plans for each patient. Salivary biomarkers present a multitude of advantages over traditional diagnostic techniques, such as non-invasiveness, cost-effectiveness, and exceptional accuracy. Consequently, they hold great potential in facilitating the timely identification and tailored management of oral cancer. This chapter aims to provide an overview of the current state and progress, while exploring the challenges and offering a glimpse into the future prospects of utilizing salivary biomarkers for the early detection of oral malignancies.