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Cancer cells can spread and migrate through various alternative mechanisms, lodging in target tissues to form a secondary tumor, known as metastasis. The tumor microenvironment is composed of an organized structure of tumor cells, immune cells, stromal cells, and extracellular matrix, forming a heterogeneous environment. Cancer cells produce cytokines and stimulatory chemical signals that induce the reprogramming of surrounding healthy cells that make up the microenvironment, aiming to promote tumor growth and achieve distant organ metastasis. The understanding of tumor cells growth and migration, evading the organism’s immune control, is crucial for the developing of new mitigation strategies.

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Mechanism of Tumor Growth and Metastasis

  • 章节

  • 发表日期：

    2024年

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  • Fernanda C. R. Dias,
  • Jaciel B. Oliveira,
  • Bruna S. S. Pinheiro,
  • Helen F. M. Pacheco,
  • Julia G. Rodrigues,
  • Jhessyka L. F. Fernandes,
  • Marcos L. M. Gomes

摘要

Cancer cells can spread and migrate through various alternative mechanisms, lodging in target tissues to form a secondary tumor, known as metastasis. The tumor microenvironment is composed of an organized structure of tumor cells, immune cells, stromal cells, and extracellular matrix, forming a heterogeneous environment. Cancer cells produce cytokines and stimulatory chemical signals that induce the reprogramming of surrounding healthy cells that make up the microenvironment, aiming to promote tumor growth and achieve distant organ metastasis. The understanding of tumor cells growth and migration, evading the organism’s immune control, is crucial for the developing of new mitigation strategies.