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The intricate relationship between the gut microbiome and gastrointestinal cancers has become a focal point in cancer research. This abstract delves into the dualistic role of the gut microbiome and its metabolites as potential promoters or inhibitors of gastrointestinal cancers. The gut microbiome, a complex ecosystem of microorganisms residing in the gastrointestinal tract, plays a pivotal role in maintaining homeostasis and influencing host physiology. Recent investigations have revealed that alterations in the composition and function of the gut microbiota, as well as shifts in metabolite profiles, can contribute to the initiation and progression of gastrointestinal cancers. This chapter reviews literature exploring the mechanisms by which specific microbial communities and their metabolic by-products may either promote tumorigenesis or exert protective effects in the gastrointestinal environment. Insights gained from understanding these intricate interactions hold promise for developing targeted interventions that leverage the gut microbiome and its metabolites for therapeutic purposes in gastrointestinal cancer prevention and treatment.

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Gut Microbiome and the Role of Its Metabolites as Promoters or Inhibitors in Gastrointestinal Cancers

  • 章节

  • 发表日期：

    2024年

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  • Monica Profir,
  • Oana Alexandra Roşu,
  • Bogdan Severus Gaspar,
  • Sanda Maria Cretoiu

摘要

The intricate relationship between the gut microbiome and gastrointestinal cancers has become a focal point in cancer research. This abstract delves into the dualistic role of the gut microbiome and its metabolites as potential promoters or inhibitors of gastrointestinal cancers. The gut microbiome, a complex ecosystem of microorganisms residing in the gastrointestinal tract, plays a pivotal role in maintaining homeostasis and influencing host physiology. Recent investigations have revealed that alterations in the composition and function of the gut microbiota, as well as shifts in metabolite profiles, can contribute to the initiation and progression of gastrointestinal cancers. This chapter reviews literature exploring the mechanisms by which specific microbial communities and their metabolic by-products may either promote tumorigenesis or exert protective effects in the gastrointestinal environment. Insights gained from understanding these intricate interactions hold promise for developing targeted interventions that leverage the gut microbiome and its metabolites for therapeutic purposes in gastrointestinal cancer prevention and treatment.