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Pediatric bone sarcomas are rare and aggressive cancers that pose significant treatment challenges. Traditional chemotherapy and surgery have limitations in achieving complete remission, especially in cases of metastatic disease. Nanodrug delivery systems offer a promising approach to overcome these limitations by delivering therapeutic agents directly to the tumor site with increased efficacy and reduced toxicity. In this chapter, we discuss recent advances in the use of nanodrug delivery in the treatment of pediatric bone sarcomas, covering organic nanoparticles (NPs), including liposomes, polymeric NPs, micelles, and dendrimers as well as inorganic NPs. We also highlight the potential of combining nanodrug delivery with other therapies, such as immunotherapy and gene therapy, to enhance treatment outcomes. Overall, the use of nanodrug delivery systems holds great promise for improving pediatric bone sarcoma outcomes in patients.

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Enhancing Treatment Efficacy for Aggressive Pediatric Bone Sarcomas: The Promise of Nanodrug Delivery

  • 章节

  • 发表日期：

    2024年

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  • Maryam Mohsenian,
  • Niloofar Masoumi,
  • Hediyeh Baghsheikhi,
  • Somayeh Ghafari,
  • Noosha Samieefar,
  • Nima Rezaei

摘要

Pediatric bone sarcomas are rare and aggressive cancers that pose significant treatment challenges. Traditional chemotherapy and surgery have limitations in achieving complete remission, especially in cases of metastatic disease. Nanodrug delivery systems offer a promising approach to overcome these limitations by delivering therapeutic agents directly to the tumor site with increased efficacy and reduced toxicity. In this chapter, we discuss recent advances in the use of nanodrug delivery in the treatment of pediatric bone sarcomas, covering organic nanoparticles (NPs), including liposomes, polymeric NPs, micelles, and dendrimers as well as inorganic NPs. We also highlight the potential of combining nanodrug delivery with other therapies, such as immunotherapy and gene therapy, to enhance treatment outcomes. Overall, the use of nanodrug delivery systems holds great promise for improving pediatric bone sarcoma outcomes in patients.