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Study Objectives: <p>Mandibular distraction osteogenesis (MDO) is recommended for children with craniofacial microsomia (CFM) and obstructive sleep apnea (OSA). However, its efficacy remains limited, with success rates of 36.4–60%. The role of adenoid hypertrophy (AH) in persistent OSA post-MDO has not been been fully investigated. This study aimed to evaluate the role of AH in influencing MDO outcomes and to explore its contribution to the pathophysiology and treatment of OSA in patients with CFM.</p> Methods: <p>A retrospective analysis was conducted on 72 patients with CFM undergoing MDO. Preoperative adenoid size was assessed using adenoid/nasopharyngeal ratios from cranial computed tomography scans. Polysomnographic data, including preoperative and postoperative obstructive apnea-hypopnea index, were analyzed. Patients were classified into effective and ineffective groups based on postoperative OSA improvement. Statistical correlations between adenoid/nasopharyngeal ratios, OSA severity, Pruzansky-Kaban classification and treatment outcomes were examined.</p> Results: <p>AH prevalence among patients with CFM with OSA was 61.1%. Adenoid/nasopharyngeal ratios correlated with postoperative obstructive apnea-hypopnea index (<i>r</i> = .261, <i>P</i> = .027), but not with preoperative obstructive apnea-hypopnea index. The ineffective group had higher adenoid/nasopharyngeal ratios than the effective group (0.69 ± 0.13 vs 0.64 ± 0.12). Overall, the MDO effectiveness rate was 47.22%, with greater improvement observed in patients with severe OSA. No significant association was found between the Pruzansky-Kaban classification and either OSA severity or MDO treatment outcomes.</p> Conclusions: <p>AH plays a significant role in persistent OSA post-MDO, particularly in mild to moderate cases. Routine preoperative assessment of AH, combined with targeted interventions such as adenoidectomy when indicated, may improve treatment outcomes. These findings underscore the importance of addressing both skeletal and soft tissue factors in the comprehensive management of OSA in patients with CFM.</p> Citation: <p>Liang Y, Cheng W, Shu K, et&#xa0;al. The role of adenoid hypertrophy in obstructive sleep apnea outcomes post-mandibular distraction osteogenesis in patients with craniofacial microsomia. <i>J Clin Sleep Med</i>. 2025;21(11):1839–1845.</p>

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The role of adenoid hypertrophy in obstructive sleep apnea outcomes post-mandibular distraction osteogenesis in patients with craniofacial microsomia

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • Yingxiang Liang,
  • Wenjie Cheng,
  • Kaiyi Shu,
  • Lunkun Ma,
  • Cheng Ke,
  • Xi Xu,
  • Shanbaga Zhao,
  • Lei Li,
  • Zhiyong Zhang,
  • Wei Liu

摘要

Study Objectives:

Mandibular distraction osteogenesis (MDO) is recommended for children with craniofacial microsomia (CFM) and obstructive sleep apnea (OSA). However, its efficacy remains limited, with success rates of 36.4–60%. The role of adenoid hypertrophy (AH) in persistent OSA post-MDO has not been been fully investigated. This study aimed to evaluate the role of AH in influencing MDO outcomes and to explore its contribution to the pathophysiology and treatment of OSA in patients with CFM.

Methods:

A retrospective analysis was conducted on 72 patients with CFM undergoing MDO. Preoperative adenoid size was assessed using adenoid/nasopharyngeal ratios from cranial computed tomography scans. Polysomnographic data, including preoperative and postoperative obstructive apnea-hypopnea index, were analyzed. Patients were classified into effective and ineffective groups based on postoperative OSA improvement. Statistical correlations between adenoid/nasopharyngeal ratios, OSA severity, Pruzansky-Kaban classification and treatment outcomes were examined.

Results:

AH prevalence among patients with CFM with OSA was 61.1%. Adenoid/nasopharyngeal ratios correlated with postoperative obstructive apnea-hypopnea index (r = .261, P = .027), but not with preoperative obstructive apnea-hypopnea index. The ineffective group had higher adenoid/nasopharyngeal ratios than the effective group (0.69 ± 0.13 vs 0.64 ± 0.12). Overall, the MDO effectiveness rate was 47.22%, with greater improvement observed in patients with severe OSA. No significant association was found between the Pruzansky-Kaban classification and either OSA severity or MDO treatment outcomes.

Conclusions:

AH plays a significant role in persistent OSA post-MDO, particularly in mild to moderate cases. Routine preoperative assessment of AH, combined with targeted interventions such as adenoidectomy when indicated, may improve treatment outcomes. These findings underscore the importance of addressing both skeletal and soft tissue factors in the comprehensive management of OSA in patients with CFM.

Citation:

Liang Y, Cheng W, Shu K, et al. The role of adenoid hypertrophy in obstructive sleep apnea outcomes post-mandibular distraction osteogenesis in patients with craniofacial microsomia. J Clin Sleep Med. 2025;21(11):1839–1845.