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<p>Prior studies have shown that a mandibular advancement device (MAD) is an effective nonsurgical treatment for obstructive sleep apnea. Most studies were performed in primarily White populations. However, East Asians have restrictive craniofacial features, such as a reduced cranial base, maxilla, and retropalatal space, which may affect their response to treatment. The objective of this study was to systematically review the use of MAD in East Asian patients and determine the effectiveness of MAD in this population. The PubMed, Embase, Scopus, CINAHL, Web of Science, and Cochrane Library databases were searched up to January 15, 2024. Studies that investigated the effects of MAD on the apnea-hypopnea index, oxygen saturation, blood pressure, and Epworth Sleepiness Scale score specifically for East Asian patients were included. Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed for data extraction. Twelve studies with 382 patients were included. The pooled mean reduction in apnea-hypopnea index was 19.1 (95% confidence interval [CI] = −23.9; −14.3, <i>I</i><sup>2</sup> = 91%). The improvements in the minimal and mean oxygen saturation were 6.0% (95% CI = 4.4; 7.5, <i>I</i><sup>2</sup> = 28%) and 1.2% (95% CI = −0.2; 2.6, <i>I</i><sup>2</sup> = 92%), respectively. Oxygen desaturation index was also reduced by 13.6 (3 studies, 95% CI = 23.9; −3.3, <i>I</i><sup>2</sup> = 92%). Systolic and diastolic pressure changes were modest at −4.4 (9% CI = −11.3; 2.4, <i>I</i><sup>2</sup> = 88%) and −3.3 (95% CI = −6.3; −0.3, <i>I</i><sup>2</sup> = 55%), respectively. Epworth Sleepiness Scale score had a reduction of 2.0 (95% CI = −3.3; −0.7, <i>I</i><sup>2</sup> = 66%). MAD is an effective device for the management of East Asian patients with obstructive sleep apnea. Although treatment success is expected in most patients, complete resolution is unlikely.</p> Citation: <p>Yong CW, Quah B, Colpani JT, Lee FKF, Loh EE-M, Wong RCW. Effectiveness of mandibular advancement devices in obstructive sleep apnea therapy for East Asian patients: a systematic review and meta-analysis. <i>J Clin Sleep Med.</i> 2025;21(7):1261–1271.</p>

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Effectiveness of mandibular advancement devices in obstructive sleep apnea therapy for East Asian patients: a systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • Chee Weng Yong,
  • Bernadette Quah,
  • Juliana Tereza Colpani,
  • Frank Kong Fei Lee,
  • Eugene Eu-Min Loh,
  • Raymond Chung Wen Wong

摘要

Prior studies have shown that a mandibular advancement device (MAD) is an effective nonsurgical treatment for obstructive sleep apnea. Most studies were performed in primarily White populations. However, East Asians have restrictive craniofacial features, such as a reduced cranial base, maxilla, and retropalatal space, which may affect their response to treatment. The objective of this study was to systematically review the use of MAD in East Asian patients and determine the effectiveness of MAD in this population. The PubMed, Embase, Scopus, CINAHL, Web of Science, and Cochrane Library databases were searched up to January 15, 2024. Studies that investigated the effects of MAD on the apnea-hypopnea index, oxygen saturation, blood pressure, and Epworth Sleepiness Scale score specifically for East Asian patients were included. Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed for data extraction. Twelve studies with 382 patients were included. The pooled mean reduction in apnea-hypopnea index was 19.1 (95% confidence interval [CI] = −23.9; −14.3, I2 = 91%). The improvements in the minimal and mean oxygen saturation were 6.0% (95% CI = 4.4; 7.5, I2 = 28%) and 1.2% (95% CI = −0.2; 2.6, I2 = 92%), respectively. Oxygen desaturation index was also reduced by 13.6 (3 studies, 95% CI = 23.9; −3.3, I2 = 92%). Systolic and diastolic pressure changes were modest at −4.4 (9% CI = −11.3; 2.4, I2 = 88%) and −3.3 (95% CI = −6.3; −0.3, I2 = 55%), respectively. Epworth Sleepiness Scale score had a reduction of 2.0 (95% CI = −3.3; −0.7, I2 = 66%). MAD is an effective device for the management of East Asian patients with obstructive sleep apnea. Although treatment success is expected in most patients, complete resolution is unlikely.

Citation:

Yong CW, Quah B, Colpani JT, Lee FKF, Loh EE-M, Wong RCW. Effectiveness of mandibular advancement devices in obstructive sleep apnea therapy for East Asian patients: a systematic review and meta-analysis. J Clin Sleep Med. 2025;21(7):1261–1271.