Abstract <p>The purpose of this study is to perform a comprehensive radioecological assessment of Okchuchay and Basitchay rivers in Zangilan region of Azerbaijan. The main objective of the article and research is to assess the level of radioactive contamination, as well as the amount of heavy metal pollutants and organochlorine pesticides in water, sediment and soil samples taken from these major transboundary rivers, which are important for agriculture and drinking water. Samples were taken from six zones of Zangilan region. Laboratory analyzes were performed using gamma spectrometry for radionuclides, atomic absorption spectrometry for heavy metals, and gas chromatography for pesticide residues. The study used rigorous sampling and analytical procedures to ensure accurate and reliable data. Additionally, the parameters of the water samples collected were measured using appropriate devices, and all the results are presented in tables. This study highlights the urgent need for effective environmental management and restoration strategies to address pollution in the Okchuchay and Basitchay basins. Urgent measures must be taken to reduce pollution and protect the health of ecosystems and local populations that depend on these water resources. It is important to implement complex monitoring and remediation programs for sustainable environmental management in Zangilan region.</p>