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Abstract <p>The default mode network (DMN), also referred to as the “Passive Mode Brain Network” (PMBN), serves as a network of active brain regions while restfully stated. An abnormal homogeneity of the DMN network has been implicated in the first episode of schizophrenia, a mental disorder characterized by perceptual disturbances. This study aimed to investigate the activity and functional connectivity of the DMN in female schizophrenia patients using an innovative brain activity localization technique known as the “Virtually implanted electrode”. EEG was registered in 22 female patients diagnosed with schizophrenia, including 17 cases of F20, 3 cases of F23, and 22 healthy controls, being in a state of quiet wakefulness. The results indicated a complex system of changes in schizophrenia patients compared to controls, attributed to weakening connections originating from structures with reduced activity and reinforcing of other connections, including inhibitory ones. These findings underscore the neurobiological basis of schizophrenia, investigating the DMN.</p>

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Default Brain System in Schizophrenia

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • A. Vartanov,
  • M. Krysko,
  • D. Leonovich,
  • O. Shevaldova,
  • S. Mirova,
  • A. Zeltser,
  • V. Zakurazhnaia,
  • A. Ochneva,
  • D. Andreyuk,
  • G. Kostyuk

摘要

Abstract

The default mode network (DMN), also referred to as the “Passive Mode Brain Network” (PMBN), serves as a network of active brain regions while restfully stated. An abnormal homogeneity of the DMN network has been implicated in the first episode of schizophrenia, a mental disorder characterized by perceptual disturbances. This study aimed to investigate the activity and functional connectivity of the DMN in female schizophrenia patients using an innovative brain activity localization technique known as the “Virtually implanted electrode”. EEG was registered in 22 female patients diagnosed with schizophrenia, including 17 cases of F20, 3 cases of F23, and 22 healthy controls, being in a state of quiet wakefulness. The results indicated a complex system of changes in schizophrenia patients compared to controls, attributed to weakening connections originating from structures with reduced activity and reinforcing of other connections, including inhibitory ones. These findings underscore the neurobiological basis of schizophrenia, investigating the DMN.