Scholarlink

Abstract <p>One of the factors contributing to the development of colorectal cancer is inflammation. Chronic ulcerative colitis may be the cause of colitis-associated colorectal cancer (CAC) in 1.6–3.7% of cases. The main regulator of the cellular response to inflammation is the NF-κB protein, which induces the expression and synthesis of the transcription factor HIF-1α (Hypoxia-Inducible Factor 1α) due to the presence of a binding site in the corresponding gene. Oxidative stress that occurs during the inflammatory process often leads to mutations in cells. The DNA of rapidly proliferating colonic epithelial cells becomes a target for reactive oxygen species, eventually leading to tumor initiation and progression. The rate of CAC development depends largely on the initial hypoxia resistance of organisms. Susceptible to hypoxia animals have faster rates of CAC initiation and progression compared to tolerant, which is characterized by a higher frequency of adenocarcinoma development, high expression levels of <i>Hif3a</i>, <i>Vegf</i>, <i>Tnfa</i>, <i>Il10</i>, <i>Tgfb</i>, <i>Cmet</i>, <i>Egf</i>, <i>Egfr</i>, <i>Bax</i>, <i>Muc1,</i> and <i>Cldn7</i> genes in tumors, pronounced changes in hematological parameters, and imbalance of lymphocyte subpopulations in tumors, mesenteric lymph nodes, and blood. Understanding the interrelation mechanisms of hypoxia resistance, HIF activity, peculiarities of the chronic inflammatory and tumor processes course is necessary for the development of new approaches to personalized therapy of diseases accompanied by oxygen deficiency.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The Role of Hypoxia and HIF Transcription Factors in the Development of Ulcerative Colitis and Associated Colorectal Cancer

  • 期刊论文

  • 发表日期：

    2025年6月1日

查看全文
  • M. V. Silina,
  • D. Sh. Dzhalilova,
  • O. V. Makarova

摘要

Abstract

One of the factors contributing to the development of colorectal cancer is inflammation. Chronic ulcerative colitis may be the cause of colitis-associated colorectal cancer (CAC) in 1.6–3.7% of cases. The main regulator of the cellular response to inflammation is the NF-κB protein, which induces the expression and synthesis of the transcription factor HIF-1α (Hypoxia-Inducible Factor 1α) due to the presence of a binding site in the corresponding gene. Oxidative stress that occurs during the inflammatory process often leads to mutations in cells. The DNA of rapidly proliferating colonic epithelial cells becomes a target for reactive oxygen species, eventually leading to tumor initiation and progression. The rate of CAC development depends largely on the initial hypoxia resistance of organisms. Susceptible to hypoxia animals have faster rates of CAC initiation and progression compared to tolerant, which is characterized by a higher frequency of adenocarcinoma development, high expression levels of Hif3a, Vegf, Tnfa, Il10, Tgfb, Cmet, Egf, Egfr, Bax, Muc1, and Cldn7 genes in tumors, pronounced changes in hematological parameters, and imbalance of lymphocyte subpopulations in tumors, mesenteric lymph nodes, and blood. Understanding the interrelation mechanisms of hypoxia resistance, HIF activity, peculiarities of the chronic inflammatory and tumor processes course is necessary for the development of new approaches to personalized therapy of diseases accompanied by oxygen deficiency.