Abstract <p>Secretion of von Willebrand factor by inflamed endothelium is considered one of the biophysical pathways initiating microvascular thrombosis in infectious diseases. At the initial stage of this process, the attachment of the first layer of platelets to von Willebrand factor forms the foundation, while mechanical and hydrodynamic phenomena exert a significant influence on the dynamics of thrombosis. In the present study, the features of platelet adhesion biomechanics to inflamed endothelium in a microvessel are investigated using computer modeling methods. Calculations are performed over a range of haemodynamic parameters characteristic of small-sized arterioles. The results demonstrate that platelet adhesion becomes more intense with increasing blood flow velocity due to the synchronous manifestation of two physical mechanisms.</p>