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Abstract <p>Comprehensive immunophenotyping of sarcoma cell cultures was performed for expression of tumor markers associated with key biological characteristics of malignant neoplasms: TUBB3, EMT/MET, PD-L1, ERα, and ERβ. Two pairs of cell cultures with differences in molecular phenotype were formed: metastatic Mg-63 vs. primary MNNG-Hos osteosarcoma and Mg-63 osteosarcoma vs. HT-1080 fibrosarcoma. These pairs may be useful for assessing the contribution of the studied markers to various biological characteristics of tumor cells and studying the interactions between their regulatory mechanisms in mesenchymal tumors.</p>

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Comprehensive Immunophenotypic Characterization of Sarcoma Cell Cultures by Five Tumor Markers

  • 期刊论文

  • 发表日期：

    2026年6月2日

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  • T. A. Bogush,
  • A. N. Grishanina,
  • S. S. Dorzhieva,
  • E. A. Bogush,
  • A. M. Scherbakov,
  • V. Yu. Kirsanov,
  • E. N. Kosobokova,
  • M. Ya. Melnikov

摘要

Abstract

Comprehensive immunophenotyping of sarcoma cell cultures was performed for expression of tumor markers associated with key biological characteristics of malignant neoplasms: TUBB3, EMT/MET, PD-L1, ERα, and ERβ. Two pairs of cell cultures with differences in molecular phenotype were formed: metastatic Mg-63 vs. primary MNNG-Hos osteosarcoma and Mg-63 osteosarcoma vs. HT-1080 fibrosarcoma. These pairs may be useful for assessing the contribution of the studied markers to various biological characteristics of tumor cells and studying the interactions between their regulatory mechanisms in mesenchymal tumors.