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<p>Pulsatile drug delivery, in which rapid drug release is separated by defined lag periods, offers significant therapeutic advantages but is limited by the need for repeated injections and poor patient adherence. Here, we introduce the fused device (FUSED), a subcutaneous system enabling programmed multidose drug delivery through a single implantation. FUSED comprises paired delay and shot units that regulate dosing intervals and trigger pulsatile drug release, respectively. After implantation, body fluids gradually dissolve the microfuse in each delay unit, with the delay duration determined by fuse length. Once fluid reaches a shot unit, an effervescent reaction is initiated, producing rapid drug release. In vitro and in vivo evaluations demonstrated precise pulsatile release of the model antigen ovalbumin, effectively reproducing prime–boost vaccination timing and eliciting the corresponding immune response. These results suggest that FUSED may provide a viable alternative to repeated injections and improve adherence in multidose therapeutic regimens.</p>

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Subcutaneous microfuse-activated device for programmed pulsatile drug delivery

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月28日

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  • Myoung Ju Kim,
  • Han Bi Ji,
  • Yong Chan Cho,
  • Jae Chan Cho,
  • Woo Hyun Kim,
  • Gi Min Park,
  • Chang Hee Min,
  • Min Ji Kim,
  • Cho Rim Kim,
  • Jae Hoon Han,
  • Cheol Lee,
  • Mark R. Prausnitz,
  • Young Bin Choy

摘要

Pulsatile drug delivery, in which rapid drug release is separated by defined lag periods, offers significant therapeutic advantages but is limited by the need for repeated injections and poor patient adherence. Here, we introduce the fused device (FUSED), a subcutaneous system enabling programmed multidose drug delivery through a single implantation. FUSED comprises paired delay and shot units that regulate dosing intervals and trigger pulsatile drug release, respectively. After implantation, body fluids gradually dissolve the microfuse in each delay unit, with the delay duration determined by fuse length. Once fluid reaches a shot unit, an effervescent reaction is initiated, producing rapid drug release. In vitro and in vivo evaluations demonstrated precise pulsatile release of the model antigen ovalbumin, effectively reproducing prime–boost vaccination timing and eliciting the corresponding immune response. These results suggest that FUSED may provide a viable alternative to repeated injections and improve adherence in multidose therapeutic regimens.