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<p>Excessive production of reactive oxygen species (ROS) and bacterial infection are intractable obstacles for wound healing in diabetic foot ulcers. Here, we devised a novel approach using a multifunctional hydrogel to achieve self-cascade glucose depletion and ROS scavenging, thereby modifying the diabetic wound microenvironment. In this study, using polyvinyl alcohol (PVA), borax, oligomeric proanthocyanidins (OPC), and nanozymes (AuPt@PDA), a PVA/Borax/OPC/AuPt@PDA (PBON) hydrogel was prepared by a one-step process. The PBON hydrogel combined with near-infrared (NIR) treatment can match the complicated and changeable microenvironment in the diabetic high-mobility region through glucose depletion, ROS scavenging, photothermal therapy (photothermal conversion 81.9%), and deformation adaptation, thus promoting wound healing close to the hip in diabetic mice through angiogenesis and epidermal regeneration by collagen deposition. This approach provides a simple, safe, and efficient treatment for diabetic wounds in mobile regions.</p>

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Reactive oxygen species scavenging hydrogel for wound healing in diabetic mice

  • 期刊论文

  • 发表日期：

    2025年9月6日

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  • Kaiyue Liu,
  • Ruimei Jin,
  • Mengyu Yang,
  • Yachao Yu,
  • Jingmei Liu,
  • Chenghao Li,
  • Chen Zhang,
  • Hua Zhao,
  • Donghui Zhao,
  • Fangxia Guan,
  • Minghao Yao

摘要

Excessive production of reactive oxygen species (ROS) and bacterial infection are intractable obstacles for wound healing in diabetic foot ulcers. Here, we devised a novel approach using a multifunctional hydrogel to achieve self-cascade glucose depletion and ROS scavenging, thereby modifying the diabetic wound microenvironment. In this study, using polyvinyl alcohol (PVA), borax, oligomeric proanthocyanidins (OPC), and nanozymes (AuPt@PDA), a PVA/Borax/OPC/AuPt@PDA (PBON) hydrogel was prepared by a one-step process. The PBON hydrogel combined with near-infrared (NIR) treatment can match the complicated and changeable microenvironment in the diabetic high-mobility region through glucose depletion, ROS scavenging, photothermal therapy (photothermal conversion 81.9%), and deformation adaptation, thus promoting wound healing close to the hip in diabetic mice through angiogenesis and epidermal regeneration by collagen deposition. This approach provides a simple, safe, and efficient treatment for diabetic wounds in mobile regions.