Scholarlink

<p>In this paper, we numerically analyze the factors determining localization precision and resolution in single emitter localization-based imaging systems. While previous studies have considered a limited set of parameters, our numerical approach incorporates additional parameters with significant reference values, yielding a more comprehensive analysis of the results. We differentiate between the effects of additive and multiplicative noise on localization precision using numerical modeling and take the influence of the sampling frequency into account, computing the optimal sampling frequency for varying resolution requirements. Leveraging a suite of derived equations, we systematically simulate and quantify how variations in these parameters influence system performance. Furthermore, we provide guidelines for optimizing signal-to-noise ratio (SNR) requirements and pixel size selection based on point spread function (PSF) width in single emitter localization-based imaging systems. This numerically driven research offers critical insights for the analysis of more complex imaging systems.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Numerical investigation of resolution in single emitter localization-based imaging systems

  • 期刊论文

  • 发表日期：

    2025年9月3日

查看全文
  • Yueying Wang,
  • Yiwen Hu,
  • Yuehan Zhao,
  • Cuifang Kuang,
  • Xiang Hao

摘要

In this paper, we numerically analyze the factors determining localization precision and resolution in single emitter localization-based imaging systems. While previous studies have considered a limited set of parameters, our numerical approach incorporates additional parameters with significant reference values, yielding a more comprehensive analysis of the results. We differentiate between the effects of additive and multiplicative noise on localization precision using numerical modeling and take the influence of the sampling frequency into account, computing the optimal sampling frequency for varying resolution requirements. Leveraging a suite of derived equations, we systematically simulate and quantify how variations in these parameters influence system performance. Furthermore, we provide guidelines for optimizing signal-to-noise ratio (SNR) requirements and pixel size selection based on point spread function (PSF) width in single emitter localization-based imaging systems. This numerically driven research offers critical insights for the analysis of more complex imaging systems.