Scholarlink

<p>Arabinoxylans (AX) are polysaccharides with the capacity to form hydrogels that absorb large amounts of water and encapsulate biomolecules, making them suitable for biomedical applications. This study aimed to develop an AX-based hydrogel containing PLGA nanoparticles loaded with propolis extract and evaluate its potential as a wound healing dressing. The hydrogels displayed a porous microstructure resembling an imperfect honeycomb. FTIR analysis confirmed the presence of functional groups characteristic of AX and PLGA. Rheological characterization indicated a viscoelastic behavior (G′ &gt; G′′) with signs of syneresis, and the hydrogels exhibited a swelling degree of 48&#xa0;g water/g AX. Antibacterial tests showed no inhibitory effect against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. However, cytotoxicity assays using L-929 cells revealed cell viability above 90%, suggesting good biocompatibility. Overall, these results indicate that AX hydrogels incorporating PLGA nanoparticles loaded with propolis extract represent promising candidates for the development of wound healing dressings with biomedical potential.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Arabinoxylan-based hydrogels containing polymeric nanoparticles loaded with propolis extract as a potential wound dressing

  • 期刊论文

  • 发表日期：

    2025年12月24日

查看全文
  • Mayra A. Mendez-Encinas,
  • Luis G. García-Duarte,
  • Elizabeth Carvajal-Millan,
  • Manuel G. Ballesteros-Monrreal,
  • Pablo A. Mendez-Pfeiffer,
  • Jorge Marquez-Escalante,
  • Dora Valencia

摘要

Arabinoxylans (AX) are polysaccharides with the capacity to form hydrogels that absorb large amounts of water and encapsulate biomolecules, making them suitable for biomedical applications. This study aimed to develop an AX-based hydrogel containing PLGA nanoparticles loaded with propolis extract and evaluate its potential as a wound healing dressing. The hydrogels displayed a porous microstructure resembling an imperfect honeycomb. FTIR analysis confirmed the presence of functional groups characteristic of AX and PLGA. Rheological characterization indicated a viscoelastic behavior (G′ > G′′) with signs of syneresis, and the hydrogels exhibited a swelling degree of 48 g water/g AX. Antibacterial tests showed no inhibitory effect against Staphylococcus aureus and Escherichia coli. However, cytotoxicity assays using L-929 cells revealed cell viability above 90%, suggesting good biocompatibility. Overall, these results indicate that AX hydrogels incorporating PLGA nanoparticles loaded with propolis extract represent promising candidates for the development of wound healing dressings with biomedical potential.

Graphical abstract