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<p>Fluorescent nanodiamonds (FNDs) have emerged as promising tools for cell imaging, drug delivery, and other technologies. In this study, the surface of functionalized NDs was modified with an extract of the medicinal plant <i>Cissus incisa</i> to enhance their luminescence. NDs (3–6&#xa0;nm) were dispersed in distilled water with addition of one or several components: 30% hydrogen peroxide, urea, theraphthal, ascorbic acid and urea mixture, or ascorbic acid and theraphthal, then subjected to an ultrasonic bath (40&#xa0;kHz) for 15–20&#xa0;h, and functionalized with plant extract. The resulting nanoparticles were characterized by FTIR, UV–Vis, SEM, and TEM, showing red and green luminescence. The results showed that chemical and structural modifications of nanodiamond surfaces affect the luminescent properties. This work is in favor of using bioactive plant molecules associated with nanodiamonds for possible therapeutic purposes. These functionalized nanodiamonds have potential applications for serving as fluorescent markers for imaging purposes.</p> Graphical abstract <p></p>

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Synthesis and characterization of fluorescent nanodiamonds (FNDs) by functionalization with Cissus Incisa in theraphthal–containing media

  • 期刊论文

  • 发表日期：

    2025年1月10日

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  • Laura V. López De Arriba,
  • Oxana V. Kharissova,
  • Deyani Nocedo Mena,
  • Boris I. Kharisov

摘要

Fluorescent nanodiamonds (FNDs) have emerged as promising tools for cell imaging, drug delivery, and other technologies. In this study, the surface of functionalized NDs was modified with an extract of the medicinal plant Cissus incisa to enhance their luminescence. NDs (3–6 nm) were dispersed in distilled water with addition of one or several components: 30% hydrogen peroxide, urea, theraphthal, ascorbic acid and urea mixture, or ascorbic acid and theraphthal, then subjected to an ultrasonic bath (40 kHz) for 15–20 h, and functionalized with plant extract. The resulting nanoparticles were characterized by FTIR, UV–Vis, SEM, and TEM, showing red and green luminescence. The results showed that chemical and structural modifications of nanodiamond surfaces affect the luminescent properties. This work is in favor of using bioactive plant molecules associated with nanodiamonds for possible therapeutic purposes. These functionalized nanodiamonds have potential applications for serving as fluorescent markers for imaging purposes.

Graphical abstract