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<p>This study explores 3D-printed polylactic acid/bioactive glass (PLA/BG) scaffolds enhanced with extracts from <i>Curcuma longa</i> and <i>Zingiber officinale</i> (PLA/BG/CZ) for bone regeneration. These scaffolds showed controlled pore structure and supported osteoblast growth. <i>In vitro</i> tests revealed that adding the plant extracts significantly boosted cell proliferation, alkaline phosphatase activity, and calcium deposition. Scanning electron microscope (SEM) imaging showed enhanced extracellular matrix and mineralized crystal formation after 21&#xa0;days. Infrared spectroscopy (FTIR) confirmed mineralization-related bands. Overall, the incorporation of these natural extracts improved osteogenic differentiation and mineralization, highlighting their potential to enhance scaffold performance in bone tissue engineering applications.</p> Graphical abstract <p></p>

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Study of osteogenic potential of PLA/BG-based 3D-printed scaffolds reinforced with Zingiber officinale and Curcuma longa extracts

  • 期刊论文

  • 发表日期：

    2026年3月10日

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  • Cinthya M. Hernández-Minjares,
  • Laura E. Valencia-Gomez,
  • Laura A. de la Rosa,
  • Óscar A. Muñoz-Bernal,
  • Claudia A. Rodríguez-Gonzalez,
  • Santos A. Martel-Estrada,
  • David Atayde-Campos,
  • Imelda Olivas-Armendariz

摘要

This study explores 3D-printed polylactic acid/bioactive glass (PLA/BG) scaffolds enhanced with extracts from Curcuma longa and Zingiber officinale (PLA/BG/CZ) for bone regeneration. These scaffolds showed controlled pore structure and supported osteoblast growth. In vitro tests revealed that adding the plant extracts significantly boosted cell proliferation, alkaline phosphatase activity, and calcium deposition. Scanning electron microscope (SEM) imaging showed enhanced extracellular matrix and mineralized crystal formation after 21 days. Infrared spectroscopy (FTIR) confirmed mineralization-related bands. Overall, the incorporation of these natural extracts improved osteogenic differentiation and mineralization, highlighting their potential to enhance scaffold performance in bone tissue engineering applications.

Graphical abstract