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Abstract <p>Surface modifications are highly desirable for hollow fiber membranes (HFMs) to reduce protein adsorption. In this study, we developed a modification technology for the cross-linked zwitterionic copolymer PMMMSi, composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), 3-methacryloxypropyltrimethoxysilane (MPTMSi), and 3-methacryloxypropyltrimethoxysilane (MPTMSi) on cellulose acetate (CA) HFMs for maintaining water permeability by reduction of protein adsorption. The modification film with 20&#xa0;nm thickness of PMMMSi60, which consists of MPC/MPTSSi/MPTMSi = 60/20/20, on the inner surface of HFMs, could maintain water permeability. The reduction in the water flux before and after γ-globulin incubation on the PMMMSi60-modified membrane was smaller than that of the unmodified CA.</p> Graphical abstract <p></p>

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Cross-linked zwitterionic copolymer-modified cellulose acetate hollow fiber membranes to reduce protein adsorption

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月9日

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  • Shuta Otomo,
  • Tsukuru Masuda,
  • Shuji Nakatsuka,
  • Youichi Matsuo,
  • Madoka Takai

摘要

Abstract

Surface modifications are highly desirable for hollow fiber membranes (HFMs) to reduce protein adsorption. In this study, we developed a modification technology for the cross-linked zwitterionic copolymer PMMMSi, composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), 3-methacryloxypropyltrimethoxysilane (MPTMSi), and 3-methacryloxypropyltrimethoxysilane (MPTMSi) on cellulose acetate (CA) HFMs for maintaining water permeability by reduction of protein adsorption. The modification film with 20 nm thickness of PMMMSi60, which consists of MPC/MPTSSi/MPTMSi = 60/20/20, on the inner surface of HFMs, could maintain water permeability. The reduction in the water flux before and after γ-globulin incubation on the PMMMSi60-modified membrane was smaller than that of the unmodified CA.

Graphical abstract