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<p>Electrospun coatings are emerging as an alternative to conventional titanium-based implant surface modifications. Here, we developed poly (lactic acid) (PLA)/nano-hydroxyapatite (nHAp) nanofibrous coatings deposited on titanium by electrospinning. A dimethyl carbonate/acetone (1:1 ratio) solvent system was adopted as a safer and sustainable alternative to toxic solvents. Scanning electron microscopy showed uniform fibers with diameters below 550&#xa0;nm and coating thicknesses of 35–45&#xa0;µm. FTIR spectra confirmed nHAp incorporation through characteristic phosphate bands. <i>In vitro</i> degradation revealed greater weight loss and more pronounced pH reduction for PLA/nHAp coatings. These green-fabricated bioactive coatings represent a promising strategy to enhance titanium implant integration.</p> Graphical abstract <p></p>

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Biocompatible PLA/nHAp coatings for titanium implants fabricated by green electrospinning

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月23日

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  • Gianluca Ciarleglio,
  • Elisa Toto,
  • Susanna Laurenzi,
  • Maria Gabriella Santonicola

摘要

Electrospun coatings are emerging as an alternative to conventional titanium-based implant surface modifications. Here, we developed poly (lactic acid) (PLA)/nano-hydroxyapatite (nHAp) nanofibrous coatings deposited on titanium by electrospinning. A dimethyl carbonate/acetone (1:1 ratio) solvent system was adopted as a safer and sustainable alternative to toxic solvents. Scanning electron microscopy showed uniform fibers with diameters below 550 nm and coating thicknesses of 35–45 µm. FTIR spectra confirmed nHAp incorporation through characteristic phosphate bands. In vitro degradation revealed greater weight loss and more pronounced pH reduction for PLA/nHAp coatings. These green-fabricated bioactive coatings represent a promising strategy to enhance titanium implant integration.

Graphical abstract