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Abstract <p>A biodegradable stent was developed using melt-spun polydioxanone (PDO)-polycaprolactone (PCL) sheath-core microfibers, integrating the fast biodegradability of PDO with the mechanical durability of PCL. The coaxial architecture enhanced radial strength and enabled tunable degradation under physiological conditions. Compared to single-component fibers, the composite maintained clinically relevant mechanical performance while reducing stiffness over time, minimizing tissue irritation. Radial force measurements and <i>in vitro</i> degradation tests verified suitability of the microfiber for bioresorbable stent applications. The PDO-PCL sheath-core design presents a promising strategy for next-generation soft tissue stents requiring early support with controlled biodegradability.</p> Graphical abstract <p></p>

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Selective control of stent biodegradability through a sheath-core microfiber structure

  • 期刊论文

  • 发表日期：

    2025年11月23日

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  • Ju Hyang Park,
  • Ga Hee Kim,
  • Seoyeon Lee,
  • Jin Yoo,
  • Soon Ho Jang,
  • Ju-Hye Yang,
  • Taehwan Lim,
  • Jun Sik Son

摘要

Abstract

A biodegradable stent was developed using melt-spun polydioxanone (PDO)-polycaprolactone (PCL) sheath-core microfibers, integrating the fast biodegradability of PDO with the mechanical durability of PCL. The coaxial architecture enhanced radial strength and enabled tunable degradation under physiological conditions. Compared to single-component fibers, the composite maintained clinically relevant mechanical performance while reducing stiffness over time, minimizing tissue irritation. Radial force measurements and in vitro degradation tests verified suitability of the microfiber for bioresorbable stent applications. The PDO-PCL sheath-core design presents a promising strategy for next-generation soft tissue stents requiring early support with controlled biodegradability.

Graphical abstract