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<p>The study aims to fabricate PCL-Ag/PCL-CUR bilayer mat with PCL-Ag nanofiber as the top layer and PCL-CUR nanofiber as the bottom layer by sequential electrospinning for the first time. The extent of cell viability of the PCL-Ag nanofiber is &gt; 75% while it is &gt; 100% for PCL-CUR nanofiber, meeting the requirements of ISO 10993–5. The synergistic effect of Ag and CUR present in the top and bottom layers of the PCL-Ag/PCL-CUR bilayer mat has provided an enriched antibacterial activity against the growth of both gram-negative (<i>P. aeruginosa</i> and <i>E.coli</i>) and gram-positive (<i>B. subtilis</i> and <i>S. aureus</i>) bacteria.</p> Graphical abstract <p></p>

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Fabrication of electrospun PCL-Ag/PCL-CUR bilayer mat with enriched antibacterial activity by sequential electrospinning

  • 期刊论文

  • 发表日期：

    2025年10月15日

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  • E. Jayapriya,
  • P. Giftynol Elizabeth,
  • T. S. N. Sankara Narayanan,
  • K. Ravichandran,
  • S. Sivakumar,
  • K. P. Smija

摘要

The study aims to fabricate PCL-Ag/PCL-CUR bilayer mat with PCL-Ag nanofiber as the top layer and PCL-CUR nanofiber as the bottom layer by sequential electrospinning for the first time. The extent of cell viability of the PCL-Ag nanofiber is > 75% while it is > 100% for PCL-CUR nanofiber, meeting the requirements of ISO 10993–5. The synergistic effect of Ag and CUR present in the top and bottom layers of the PCL-Ag/PCL-CUR bilayer mat has provided an enriched antibacterial activity against the growth of both gram-negative (P. aeruginosa and E.coli) and gram-positive (B. subtilis and S. aureus) bacteria.

Graphical abstract