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<p>The study aims to develop a novel biomaterial for tendon regeneration, addressing the urgent need due to widespread tendon injuries. We created a composite material from GelMA microgels loaded with diclofenac sodium (DS) and bioactive glass (BG), uniquely combining anti-inflammatory and bioactive properties. Systematic characterization revealed steady DS release, excellent biocompatibility, and over 90% cell viability. In a rat tendon defect model, the composite enhanced early cell proliferation, tissue remodeling, and structural and mechanical properties over 7, 14, and 28&#xa0;days, achieving maximum load and tensile modulus similar to normal tendons, demonstrating its clinical potential.</p> Graphical abstract <p></p>

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GelMA-based injectable microgel loaded with bioactive glass and diclofenac sodium for tendon regeneration

  • 期刊论文

  • 发表日期：

    2025年8月25日

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  • Xu Jiajia,
  • Ye Shumin,
  • Liu Guangwei,
  • Sun Zhihuang,
  • Zhang Xianyu,
  • Jiang Jian,
  • Wu Guobao

摘要

The study aims to develop a novel biomaterial for tendon regeneration, addressing the urgent need due to widespread tendon injuries. We created a composite material from GelMA microgels loaded with diclofenac sodium (DS) and bioactive glass (BG), uniquely combining anti-inflammatory and bioactive properties. Systematic characterization revealed steady DS release, excellent biocompatibility, and over 90% cell viability. In a rat tendon defect model, the composite enhanced early cell proliferation, tissue remodeling, and structural and mechanical properties over 7, 14, and 28 days, achieving maximum load and tensile modulus similar to normal tendons, demonstrating its clinical potential.

Graphical abstract