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<p>In this study, SiO<sub>2</sub> nanoparticles (S) were surface-functionalized with dopamine (S-D) and organic groups (S-Org) to improve compatibility with the polyvinyl alcohol (PVA) matrix for hybrid nanofiber formation. Electrospun PVA nanofibers with varying silver nanoparticle (AgNP) contents were compared to hybrid nanofibers made by dual electrospinning: one syringe with PLA-AgNP and the other with PVA-SiO<sub>2</sub> (modified/unmodified). PVA fibers had diameters &lt; 200&#xa0;nm, but increased with SiO<sub>2</sub> addition. Surface-modified SiO<sub>2</sub> improved fiber continuity and interaction with the PVA matrix. Hybrid PLA/PVA fibers had larger diameters than pure PVA fibers, especially with S-D. AgNPs reduced bead formation and enhanced fiber uniformity. Mechanical testing showed improved tensile strength and Young’s modulus with added SiO<sub>2</sub> and AgNPs. FTIR confirmed no new chemical bonds, though all components’ peaks remained visible. Contact angle results showed enhanced hydrophilicity with AgNPs and modified SiO<sub>2</sub>. Biodegradation tests revealed AgNPs had minimal impact on weight loss. Among all samples, PLA-1%Ag/PVA-S-D showed the best structural integrity, biocompatibility, hydrophilicity, and mechanical strength. MTT assays confirmed nanofiber nontoxicity, while antibacterial tests showed strong inhibition of both Gram-positive and Gram-negative bacteria due to the combined effects of polydopamine and silver nanoparticles.</p> Graphical Abstract <p></p>

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Dual-electrospinning of PLA/PVA nanofibers reinforced with surface-modified SiO2 and silver nanoparticles for bone tissue engineering

  • 期刊论文

  • 发表日期：

    2026年7月17日

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  • Marziyeh Ranjbar-Mohammadi,
  • Golshan Hajizadeh,
  • Elnaz Esmizadeh,
  • Ali Vahidifar

摘要

In this study, SiO2 nanoparticles (S) were surface-functionalized with dopamine (S-D) and organic groups (S-Org) to improve compatibility with the polyvinyl alcohol (PVA) matrix for hybrid nanofiber formation. Electrospun PVA nanofibers with varying silver nanoparticle (AgNP) contents were compared to hybrid nanofibers made by dual electrospinning: one syringe with PLA-AgNP and the other with PVA-SiO2 (modified/unmodified). PVA fibers had diameters < 200 nm, but increased with SiO2 addition. Surface-modified SiO2 improved fiber continuity and interaction with the PVA matrix. Hybrid PLA/PVA fibers had larger diameters than pure PVA fibers, especially with S-D. AgNPs reduced bead formation and enhanced fiber uniformity. Mechanical testing showed improved tensile strength and Young’s modulus with added SiO2 and AgNPs. FTIR confirmed no new chemical bonds, though all components’ peaks remained visible. Contact angle results showed enhanced hydrophilicity with AgNPs and modified SiO2. Biodegradation tests revealed AgNPs had minimal impact on weight loss. Among all samples, PLA-1%Ag/PVA-S-D showed the best structural integrity, biocompatibility, hydrophilicity, and mechanical strength. MTT assays confirmed nanofiber nontoxicity, while antibacterial tests showed strong inhibition of both Gram-positive and Gram-negative bacteria due to the combined effects of polydopamine and silver nanoparticles.

Graphical Abstract