Scholarlink

<p>At present, small-diameter vascular grafts (&lt; 6&#xa0;mm) remain a major clinical challenge. Herein, we propose a bilayered small-diameter vascular graft composed of a dense inner layer of biomimetic multiscale-fibrous network by integrating nanofibrous bacterial cellulose (BC) and microfibrous regenerated cellulose (RC), and an interconnected macroporous outer layer of gelatin (Gel). This bilayered small-diameter vascular graft exhibits suitable mechanical performance for clinical applications. BC/RC layer displays superior hemocompatibility compared to BC layer, and its performance is comparable to that of RC layer. Moreover, BC/RC layer significantly enhances the cytocompatibility toward endothelial cells compared to BC and RC layers, as demonstrated by the results of cell proliferation, adhesion, and spreading. In addition, Gel layer with optimal pore size around 200&#xa0;μm provides a favorable microenvironment to support the growth of smooth muscle cells. Collectively, this bilayered small-diameter vascular graft represents a promising solution for vascular replacement and regeneration.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Construction of bilayered small-diameter vascular graft with dense multiscale-fibrous inner layer and interconnected macroporous outer layer

  • 期刊论文

  • 发表日期：

    2026年4月1日

查看全文
  • Zhiwei Yang,
  • Meng Li,
  • Wujie Yao,
  • Quanchao Zhang,
  • Jian Li,
  • Yizao Wan,
  • Mengna Zhang,
  • Bin Xie,
  • Jie Wang

摘要

At present, small-diameter vascular grafts (< 6 mm) remain a major clinical challenge. Herein, we propose a bilayered small-diameter vascular graft composed of a dense inner layer of biomimetic multiscale-fibrous network by integrating nanofibrous bacterial cellulose (BC) and microfibrous regenerated cellulose (RC), and an interconnected macroporous outer layer of gelatin (Gel). This bilayered small-diameter vascular graft exhibits suitable mechanical performance for clinical applications. BC/RC layer displays superior hemocompatibility compared to BC layer, and its performance is comparable to that of RC layer. Moreover, BC/RC layer significantly enhances the cytocompatibility toward endothelial cells compared to BC and RC layers, as demonstrated by the results of cell proliferation, adhesion, and spreading. In addition, Gel layer with optimal pore size around 200 μm provides a favorable microenvironment to support the growth of smooth muscle cells. Collectively, this bilayered small-diameter vascular graft represents a promising solution for vascular replacement and regeneration.

Graphical abstract