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<p>Fluorescent carbon dots (CDs) have shown great potential in bioimaging and sensing due to their excellent properties. However, their applications are often limited by emission typically in the blue-green region. Herein, natural products rhein and tyrosine were used as precursors to successfully construct red fluorescent carbon dots (R-CDs) by solvothermal method. R-CDs exhibited remarkable red fluorescence with the maximum emission at 650&#xa0;nm, high quantum yield (49.9%), and excellent stability. R-CDs could effectively penetrate the bacterial cell wall to label Staphylococcus aureus and Escherichia coli without cytotoxicity. Furthermore, Fe<sup>3+&#xa0;</sup>quenched the fluorescence by static quenching mechanism (detection limit: 0.82&#xa0;μM), while Arg restored it by hydrogen bonding (detection limit: 3.19&#xa0;μM). This formed an "on-off-on" sensing platform for the selective detection of Fe<sup>3+</sup> in real samples. The study provides a new strategy for developing multifunctional CD-based probes, demonstrating broad application potential in environmental monitoring, disease diagnosis, and bioimaging.</p> Graphic Abstract <p></p>

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Application of rhein-tyrosine-derived red fluorescent carbon dot for bacterial imaging and Fe3+ "on-off-on" fluorescence sensing detection

  • 期刊论文

  • 发表日期：

    2026年1月23日

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  • Taofeng Zhang,
  • Hongli Wang,
  • Yu Wang,
  • Maolong Chen,
  • Tan Chen,
  • Zexuan Liu,
  • Fang Wang,
  • Hui Wang,
  • Dan Xu,
  • Zhencun Cui,
  • Aimei Yang

摘要

Fluorescent carbon dots (CDs) have shown great potential in bioimaging and sensing due to their excellent properties. However, their applications are often limited by emission typically in the blue-green region. Herein, natural products rhein and tyrosine were used as precursors to successfully construct red fluorescent carbon dots (R-CDs) by solvothermal method. R-CDs exhibited remarkable red fluorescence with the maximum emission at 650 nm, high quantum yield (49.9%), and excellent stability. R-CDs could effectively penetrate the bacterial cell wall to label Staphylococcus aureus and Escherichia coli without cytotoxicity. Furthermore, Fe3+ quenched the fluorescence by static quenching mechanism (detection limit: 0.82 μM), while Arg restored it by hydrogen bonding (detection limit: 3.19 μM). This formed an "on-off-on" sensing platform for the selective detection of Fe3+ in real samples. The study provides a new strategy for developing multifunctional CD-based probes, demonstrating broad application potential in environmental monitoring, disease diagnosis, and bioimaging.

Graphic Abstract