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<p>This study explores the development of a novel biocomposite for interference screws, addressing the limitations of traditional metal and polymer materials in orthopedic applications. The biocomposite comprises 92.5% polylactic acid (PLA), 5% polyethylene glycol (PEG), and 2.5% hydroxyapatite (HA), designed to enhance mechanical performance and biocompatibility. Mechanical testing revealed a stress at break of 51.1&#xa0;MPa and an elongation at break of 9.25%, demonstrating improved strength and ductility over pure PLA. Scanning electron microscopy indicated increased surface roughness, which may reduce brittleness and enhance cell attachment. Cytotoxicity assessments using the MTT assay confirmed excellent cytocompatibility. <i>In vivo</i> implantation in mice over seven months showed no signs of inflammation or material degradation, indicating long-term stability. These findings suggest that this biocomposite is a promising candidate for biomedical applications, particularly in interference screw production, offering superior mechanical properties, biocompatibility, and extended <i>in vivo</i> stability.</p> Graphical abstract <p></p>

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In vivo biocompatibility assessment of polylactic acid-polyethylene glycol-hydroxyapatite biocomposite: A promising material for interference screws

  • 期刊论文

  • 发表日期：

    2025年12月24日

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  • Anita Shahifar,
  • Hamed Bagheri,
  • Mojdeh Salehnia

摘要

This study explores the development of a novel biocomposite for interference screws, addressing the limitations of traditional metal and polymer materials in orthopedic applications. The biocomposite comprises 92.5% polylactic acid (PLA), 5% polyethylene glycol (PEG), and 2.5% hydroxyapatite (HA), designed to enhance mechanical performance and biocompatibility. Mechanical testing revealed a stress at break of 51.1 MPa and an elongation at break of 9.25%, demonstrating improved strength and ductility over pure PLA. Scanning electron microscopy indicated increased surface roughness, which may reduce brittleness and enhance cell attachment. Cytotoxicity assessments using the MTT assay confirmed excellent cytocompatibility. In vivo implantation in mice over seven months showed no signs of inflammation or material degradation, indicating long-term stability. These findings suggest that this biocomposite is a promising candidate for biomedical applications, particularly in interference screw production, offering superior mechanical properties, biocompatibility, and extended in vivo stability.

Graphical abstract