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<p>Nanotechnology is gaining prominence in biomedicine due to its ability to address diseases like breast cancer through highly effective nanomaterials. Their unique physicochemical properties enable the encapsulation of therapeutic agents and targeted delivery, minimizing side effects of conventional treatments. In this study, a tin(IV) compound was used for its anticancer activity, while folic acid served as a targeting agent due to its affinity for tumor cell membranes. To overcome common issues such as nanoparticle aggregation and poor aqueous dispersion, formulations with varying concentrations of N-(triethoxysilylpropyl)-o-polyethylene oxide urethane (PEG) were developed. The materials were characterized, and their performance in biological media was assessed. Cytotoxicity was tested in the MCF-7 breast cancer cell line, and toxicity was evaluated in Hek 293T cells. Among the tested nanomaterials, the final materials functionalized with 5% of the polymer, exhibited the best antitumor activity, highlighting their potential for further <i>in vivo</i> development in cancer therapy.</p> Graphical abstract <p></p>

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Synthesis of mesoporous silica nanoparticles with organotin and folic acid: Influence of PEG concentration in the formulation

  • 期刊论文

  • 发表日期：

    2025年9月9日

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  • Victoria García-Almodóvar,
  • Julia D. Magdaleno,
  • Diana Díaz-García,
  • Sanjiv Prashar,
  • Santiago Gómez-Ruiz

摘要

Nanotechnology is gaining prominence in biomedicine due to its ability to address diseases like breast cancer through highly effective nanomaterials. Their unique physicochemical properties enable the encapsulation of therapeutic agents and targeted delivery, minimizing side effects of conventional treatments. In this study, a tin(IV) compound was used for its anticancer activity, while folic acid served as a targeting agent due to its affinity for tumor cell membranes. To overcome common issues such as nanoparticle aggregation and poor aqueous dispersion, formulations with varying concentrations of N-(triethoxysilylpropyl)-o-polyethylene oxide urethane (PEG) were developed. The materials were characterized, and their performance in biological media was assessed. Cytotoxicity was tested in the MCF-7 breast cancer cell line, and toxicity was evaluated in Hek 293T cells. Among the tested nanomaterials, the final materials functionalized with 5% of the polymer, exhibited the best antitumor activity, highlighting their potential for further in vivo development in cancer therapy.

Graphical abstract