Scholarlink

Background <p>The roles and benefits of locoregional treatments in metastatic neuroendocrine tumors (NETs) need reassessment for contemporary decision making and counseling. We examined contemporary short-term outcomes of liver-directed therapy for metastatic NETs.</p> Methods <p>We conducted a population-based retrospective cohort study of patients with metastatic NETs (2000–2019) undergoing liver embolization or resection. Outcomes were 30-day major morbidity (Clavien–Dindo grade 3–5) and mortality. Logistic regression examined factors associated with outcomes in each group.</p> Results <p>Overall, 1054 patients underwent 1224 liver embolizations, and 502 liver resections were performed. Median length of hospital stay was 1 day (interquartile range [IQR] 1–4) for liver embolization and 7 days (IQR 5–9) for liver resection. Thirty-day major morbidity occurred in 10% of liver embolizations, including 40 (3.3%) deaths, and in 22.5% after liver resections, including 11 (2.2%) deaths. Factors independently associated with increased risk after liver embolization were prior embolization (odds ratio [OR] 0.64, 95% confidence interval [CI] 0.46–0.89) and combination of prior liver embolization and resection (OR 0.50, 95% CI 0.28–0.87). For liver resection, age &gt;70&#xa0;years was independently associated with increased odds of major morbidity (OR 2.08, 95% CI 1.12–3.84) and metachronous metastases with lower odds of major morbidity (OR 0.62, 95% CI 0.39–0.99).</p> Conclusion <p>In this contemporary cohort, mortality after liver embolization was comparable with that after liver resection. Prior liver-directed therapy and older age were associated with higher risk of major morbidity This information is important when discussing the use and choice of liver-directed therapies and counseling patients with metastatic NETs.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Contemporary Short-Term Outcomes of Liver-Directed Therapy for Neuroendocrine Tumor Liver Metastases

  • 期刊论文

  • 发表日期：

    2025年9月13日

查看全文
  • Léamarie Meloche-Dumas,
  • Frédéric Mercier,
  • Simron Singh,
  • Calvin Law,
  • Sten Myrehaug,
  • Wing Chan,
  • Julie Hallet

摘要

Background

The roles and benefits of locoregional treatments in metastatic neuroendocrine tumors (NETs) need reassessment for contemporary decision making and counseling. We examined contemporary short-term outcomes of liver-directed therapy for metastatic NETs.

Methods

We conducted a population-based retrospective cohort study of patients with metastatic NETs (2000–2019) undergoing liver embolization or resection. Outcomes were 30-day major morbidity (Clavien–Dindo grade 3–5) and mortality. Logistic regression examined factors associated with outcomes in each group.

Results

Overall, 1054 patients underwent 1224 liver embolizations, and 502 liver resections were performed. Median length of hospital stay was 1 day (interquartile range [IQR] 1–4) for liver embolization and 7 days (IQR 5–9) for liver resection. Thirty-day major morbidity occurred in 10% of liver embolizations, including 40 (3.3%) deaths, and in 22.5% after liver resections, including 11 (2.2%) deaths. Factors independently associated with increased risk after liver embolization were prior embolization (odds ratio [OR] 0.64, 95% confidence interval [CI] 0.46–0.89) and combination of prior liver embolization and resection (OR 0.50, 95% CI 0.28–0.87). For liver resection, age >70 years was independently associated with increased odds of major morbidity (OR 2.08, 95% CI 1.12–3.84) and metachronous metastases with lower odds of major morbidity (OR 0.62, 95% CI 0.39–0.99).

Conclusion

In this contemporary cohort, mortality after liver embolization was comparable with that after liver resection. Prior liver-directed therapy and older age were associated with higher risk of major morbidity This information is important when discussing the use and choice of liver-directed therapies and counseling patients with metastatic NETs.