Scholarlink

Background <p>Some microRNAs (miRNAs) may have potential as biomarkers for axillary lymph node metastasis (ALNM) in breast cancer.</p> Methods <p>PubMed was systematically searched from its inception to October 2023 using the search term&#xa0;’miRNA and breast cancer lymph node metastasis’&#xa0;to identify miRNAs reported in&#xa0;three or more relevant publications. Each qualifying miRNA was then paired with&#xa0;’breast cancer’&#xa0;as search terms across four databases (PubMed, Embase, Web of Science, and Cochrane Library) covering the same time span. Studies investigating&#xa0;miRNA associations with ALNM in breast cancer&#xa0;were included and the evaluation indicators (odds ratio [OR]) or standardized mean difference [SMD]) were calculated.</p> Results <p>Nine miRNAs were frequently reported to be associated with breast cancer ALNM: miR-206, miR-21, miR-155, miR-124, miR-10b, miR-30a, miR-200c, miR-4521, and miR-101. Patients with high expression of miR-155 (OR 3.41 [1.92–6.06]) or low expression of miR-200c (OR 0.36 [0.17–0.77]) were more likely to experience ALNM. Compared with patients without lymph node metastasis, patients with positive ALNM had elevated expression levels of miR-21 (SMD 1.39 [0.66–2.13]), miR-155 (SMD 0.91 [0.17–1.65]), and miR-10b (SMD 0.63 [0.02–1.23]), and decreased expression levels of miR-200c (SMD −&#xa0;0.44 [−&#xa0;0.84 to −&#xa0;0.05]) and miR-124 (SMD −&#xa0;2.29 [−&#xa0;3.93 to −&#xa0;0.65]).</p> Conclusion <p>High expression of miRNA-155, miRNA-21, and miRNA-10b, and low expression of miRNA-200c and miRNA-124, were significantly correlated with ALNM in breast cancer patients. miRNAs are expected to become biomarkers for predicting ALNM in breast cancer patients, although more clinical trials are needed for validation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

miRNAs Associated with Axillary Lymph Node Metastasis in Breast Cancer: A Systematic Review and Meta-Analysis

  • 期刊论文

  • 发表日期：

    2025年8月9日

查看全文
  • Yuan Lin,
  • Yan-Yan Wang,
  • Zhi-Bao Xu,
  • Lei Dong,
  • Can Liu,
  • Ya-Wen Wang,
  • Xu Chen,
  • Kai Zhang

摘要

Background

Some microRNAs (miRNAs) may have potential as biomarkers for axillary lymph node metastasis (ALNM) in breast cancer.

Methods

PubMed was systematically searched from its inception to October 2023 using the search term ’miRNA and breast cancer lymph node metastasis’ to identify miRNAs reported in three or more relevant publications. Each qualifying miRNA was then paired with ’breast cancer’ as search terms across four databases (PubMed, Embase, Web of Science, and Cochrane Library) covering the same time span. Studies investigating miRNA associations with ALNM in breast cancer were included and the evaluation indicators (odds ratio [OR]) or standardized mean difference [SMD]) were calculated.

Results

Nine miRNAs were frequently reported to be associated with breast cancer ALNM: miR-206, miR-21, miR-155, miR-124, miR-10b, miR-30a, miR-200c, miR-4521, and miR-101. Patients with high expression of miR-155 (OR 3.41 [1.92–6.06]) or low expression of miR-200c (OR 0.36 [0.17–0.77]) were more likely to experience ALNM. Compared with patients without lymph node metastasis, patients with positive ALNM had elevated expression levels of miR-21 (SMD 1.39 [0.66–2.13]), miR-155 (SMD 0.91 [0.17–1.65]), and miR-10b (SMD 0.63 [0.02–1.23]), and decreased expression levels of miR-200c (SMD − 0.44 [− 0.84 to − 0.05]) and miR-124 (SMD − 2.29 [− 3.93 to − 0.65]).

Conclusion

High expression of miRNA-155, miRNA-21, and miRNA-10b, and low expression of miRNA-200c and miRNA-124, were significantly correlated with ALNM in breast cancer patients. miRNAs are expected to become biomarkers for predicting ALNM in breast cancer patients, although more clinical trials are needed for validation.