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Background <p>Breast cancer (BC) is a heterogeneous disease with variable prognosis, highlighting the need for novel biomarkers and therapeutic targets. This study investigates the role of the CDO1 gene, which encodes <i>cysteine dioxygenase 1</i>, in BC progression and its potential impact on patient outcomes.</p> Materials and Methods <p>We performed stable transfection of <i>CDO1</i> in the MDA-MB231 triple negative&#xa0;BC (TNBC)&#xa0;cell line, followed by analysis of gene expression profiles using microarray technology.</p> Results <p><i>CDO1</i> is significantly upregulated in transfected cells, leading to the induction of several tumor suppressor genes, including <i>DEFB1</i>, <i>HOPX</i>, and <i>FRMD3</i>. Correlation analysis in clinical BC samples revealed significant associations between <i>CDO1</i> and other key genes, including <i>SLC1A7</i> and <i>KITLG</i>, underscoring its relevance in tumor biology. Functional assays demonstrated that <i>CDO1</i> expression is associated with increased apoptosis and reduced cell viability, suggesting a protective role against tumor progression. Additionally, we observed alterations in oncogenic pathways related to extracellular matrix and protease (<i>SGRN</i> and <i>ADAMTS1</i>), indicating that <i>CDO1</i> may alleviate metastatic potential putatively via stromal reprogramming.</p> Conclusions <p>Our findings establish <i>CDO1</i> as a significant modulator of BC behavior and highlight its potential as a biomarker for prognosis. Further research is warranted to elucidate the underlying mechanisms and explore the therapeutic implications of targeting <i>CDO1</i> in TNBC.</p>

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Exploring the Role of CDO1 in Breast Cancer: Insights into Tumor Biology and Therapeutic Potential

  • 期刊论文

  • 发表日期：

    2025年8月5日

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  • Shiori Fujino,
  • Keishi Yamashita,
  • Riku Okamoto,
  • Shumpei Shibaki,
  • Kanako Naito,
  • Hiroyuki Minoura,
  • Kyonosuke Ikemura,
  • Yu Kuroda,
  • Kota Okuno,
  • Akiko Watanabe,
  • Keiko Oki,
  • Mikiko Kidachi,
  • Yusuke Nie,
  • Takaaki Tokito,
  • Mariko Kikuchi,
  • Hiroshi Kato,
  • Takeshi Naitoh,
  • Naoki Hiki,
  • Yusuke Kumamoto,
  • Takafumi Sangai

摘要

Background

Breast cancer (BC) is a heterogeneous disease with variable prognosis, highlighting the need for novel biomarkers and therapeutic targets. This study investigates the role of the CDO1 gene, which encodes cysteine dioxygenase 1, in BC progression and its potential impact on patient outcomes.

Materials and Methods

We performed stable transfection of CDO1 in the MDA-MB231 triple negative BC (TNBC) cell line, followed by analysis of gene expression profiles using microarray technology.

Results

CDO1 is significantly upregulated in transfected cells, leading to the induction of several tumor suppressor genes, including DEFB1, HOPX, and FRMD3. Correlation analysis in clinical BC samples revealed significant associations between CDO1 and other key genes, including SLC1A7 and KITLG, underscoring its relevance in tumor biology. Functional assays demonstrated that CDO1 expression is associated with increased apoptosis and reduced cell viability, suggesting a protective role against tumor progression. Additionally, we observed alterations in oncogenic pathways related to extracellular matrix and protease (SGRN and ADAMTS1), indicating that CDO1 may alleviate metastatic potential putatively via stromal reprogramming.

Conclusions

Our findings establish CDO1 as a significant modulator of BC behavior and highlight its potential as a biomarker for prognosis. Further research is warranted to elucidate the underlying mechanisms and explore the therapeutic implications of targeting CDO1 in TNBC.