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Background <p>Sociodemographic disparities in cancer care outcomes are often related to delayed or limited care access. However, it is unknown whether outcome differences persist after establishing high-level care. This study evaluated the relationship between rectal cancer outcomes and sociodemographic status at academic cancer centers.</p> Patients and Methods <p>A retrospective cohort study of patients with rectal cancer treated at academic cancer centers was conducted utilizing the National Cancer Database. Primary outcome was overall survival, while secondary outcomes included 30- and 90-day mortality, time from diagnosis to treatments, hospital readmission rates, and hospital length of stay.</p> Results <p>Of the 127,023 patients, median age was 62.7 years (SD 11.92), 59.3% were male, 80.3% were white, and 39.4% presented with stage III disease. After adjustment, Black patients had the worst overall survival (HR 1.10, 95% CI 1.01–1.19, <i>p</i> = 0.016). Private insurance status conferred overall survival benefit (HR 0.66, 95% CI 0.58–0.75, <i>p </i>&lt; 0.001) as well as the best protection against 30- and 90- day postoperative mortality (30-day OR 0.31, 95% CI 0.10–0.97, <i>p </i>= 0.044; 90-day OR 0.37, 95% CI 0.16–0.83, <i>p </i>= 0.015). Black patients experienced longer time to first treatment than their white counterparts, with a delay of 3.23&#xa0;days (95% CI 1.87–4.58, <i>p </i>&lt; 0.001).</p> Conclusions <p>This study demonstrated the existence of sociodemographic disparities even within the walls of academic institutions, where care should be evidence-based, standardized, comprehensive, and equitable. When analyzing causal pathways, delays in time to treatment initiation may be contributing to these outcomes, but may be modifiable.</p>

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Sociodemographic Disparities in Rectal Cancer Outcomes within Academic Cancer Centers

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月2日

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  • Susan J. Kim,
  • Chengli Shen,
  • Mohamad El Moheb,
  • Kaelyn C. Cummins,
  • Samantha M. Ruff,
  • Russell Witt,
  • Allan Tsung

摘要

Background

Sociodemographic disparities in cancer care outcomes are often related to delayed or limited care access. However, it is unknown whether outcome differences persist after establishing high-level care. This study evaluated the relationship between rectal cancer outcomes and sociodemographic status at academic cancer centers.

Patients and Methods

A retrospective cohort study of patients with rectal cancer treated at academic cancer centers was conducted utilizing the National Cancer Database. Primary outcome was overall survival, while secondary outcomes included 30- and 90-day mortality, time from diagnosis to treatments, hospital readmission rates, and hospital length of stay.

Results

Of the 127,023 patients, median age was 62.7 years (SD 11.92), 59.3% were male, 80.3% were white, and 39.4% presented with stage III disease. After adjustment, Black patients had the worst overall survival (HR 1.10, 95% CI 1.01–1.19, p = 0.016). Private insurance status conferred overall survival benefit (HR 0.66, 95% CI 0.58–0.75, p < 0.001) as well as the best protection against 30- and 90- day postoperative mortality (30-day OR 0.31, 95% CI 0.10–0.97, p = 0.044; 90-day OR 0.37, 95% CI 0.16–0.83, p = 0.015). Black patients experienced longer time to first treatment than their white counterparts, with a delay of 3.23 days (95% CI 1.87–4.58, p < 0.001).

Conclusions

This study demonstrated the existence of sociodemographic disparities even within the walls of academic institutions, where care should be evidence-based, standardized, comprehensive, and equitable. When analyzing causal pathways, delays in time to treatment initiation may be contributing to these outcomes, but may be modifiable.