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<p>Allergic skin disease conditions represent a significant global health challenge, with conventional therapies frequently associated with local dermal irritation and systemic adverse effects. Nanotechnology-enabled transdermal drug delivery platforms present innovative approaches for the targeted and efficient administration of natural drugs. This paper presents an overview of the application of nanocarriers, including polymeric nanoparticles, lipid-based nanocarriers, and inorganic nanostructures, for managing allergic skin diseases by enhancing the solubility of natural drugs, improving transdermal permeation, and facilitating site-specific targeting. The synergistic integration of microneedle arrays and hydrogel matrices for sustained release and precise delivery is also analyzed. Furthermore, the potential of stimuli-responsive smart delivery systems to modulate the lesion microenvironment is explored. In future advancements, integrating artificial intelligence into the rational design of nanocarriers, developing 3D skin organoid models, and establishing dynamic efficacy assessment systems can expedite the clinical translation of novel nanomedicines. This approach offers a robust theoretical foundation and technical support for personalized therapy in allergic skin disease conditions.</p> Graphical Abstract <p></p>

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Progress and Prospects of Transdermal Treatment of Allergic Skin Diseases with Natural Drugs based on Nanotechnology

  • 期刊论文

  • 发表日期：

    2025年11月6日

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  • Wenfei Lu,
  • Jiansheng Cao,
  • Ying Lv,
  • Meng Li,
  • Ye Tang,
  • Yufei Feng

摘要

Allergic skin disease conditions represent a significant global health challenge, with conventional therapies frequently associated with local dermal irritation and systemic adverse effects. Nanotechnology-enabled transdermal drug delivery platforms present innovative approaches for the targeted and efficient administration of natural drugs. This paper presents an overview of the application of nanocarriers, including polymeric nanoparticles, lipid-based nanocarriers, and inorganic nanostructures, for managing allergic skin diseases by enhancing the solubility of natural drugs, improving transdermal permeation, and facilitating site-specific targeting. The synergistic integration of microneedle arrays and hydrogel matrices for sustained release and precise delivery is also analyzed. Furthermore, the potential of stimuli-responsive smart delivery systems to modulate the lesion microenvironment is explored. In future advancements, integrating artificial intelligence into the rational design of nanocarriers, developing 3D skin organoid models, and establishing dynamic efficacy assessment systems can expedite the clinical translation of novel nanomedicines. This approach offers a robust theoretical foundation and technical support for personalized therapy in allergic skin disease conditions.

Graphical Abstract