Scholarlink

<p>Diabetes negatively impacts the male reproductive system and <i>Heliotropium indicum</i> has been utilized in folklore to treat various human diseases, including female infertility owing to its wide spectrum of pharmacological activity. Thus, the present study investigated the effect of <i>H. indicum</i> leaf extract (AHI) on male reproductive parameters in diabetic rats. Thirty Wistar rats were randomly grouped into five; all groups except the control were fed a high-fat diet for 14&#xa0;days and 35&#xa0;mg/kg streptozotocin was administered. Group 3 was treated with 20&#xa0;mg/kg of acarbose (AC), while groups 4 and 5 received 50 and 100&#xa0;mg/kg AHI, respectively. The blood glucose level, antioxidant status, hormonal level, sperm quality, and morphology were assessed. Furthermore, the histological and histomorphometric parameters were examined. Findings in this study revealed a significant (<i>p</i> &lt; 0.05) decrease in antioxidant status, sperm quality, and hormonal level in the HFD/STZ group compared with the control. However, treatment with AHI significantly improved antioxidant status, sperm quality, and hormonal level concerning the HFD/STZ untreated group. Moreover, treatment with <i>H. indicum</i> restored the altered testicular histology and histomorphometric parameters. This study showed that <i>H. indicum</i> markedly improves male reproductive parameters in diabetic rats, and could therefore be a promising alternative therapy in combating male reproductive disorders associated with diabetes.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Aqueous Heliotropium indicum Leaf Extract Ameliorates Male Reproductive System Dysfunction in High-Fat Diet/Streptozotocin-Induced Diabetes Model

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月25日

查看全文
  • Adeniyi A. Adebayo,
  • Leye J. Babatola,
  • Teniola O. AdebayoSojibola

摘要

Diabetes negatively impacts the male reproductive system and Heliotropium indicum has been utilized in folklore to treat various human diseases, including female infertility owing to its wide spectrum of pharmacological activity. Thus, the present study investigated the effect of H. indicum leaf extract (AHI) on male reproductive parameters in diabetic rats. Thirty Wistar rats were randomly grouped into five; all groups except the control were fed a high-fat diet for 14 days and 35 mg/kg streptozotocin was administered. Group 3 was treated with 20 mg/kg of acarbose (AC), while groups 4 and 5 received 50 and 100 mg/kg AHI, respectively. The blood glucose level, antioxidant status, hormonal level, sperm quality, and morphology were assessed. Furthermore, the histological and histomorphometric parameters were examined. Findings in this study revealed a significant (p < 0.05) decrease in antioxidant status, sperm quality, and hormonal level in the HFD/STZ group compared with the control. However, treatment with AHI significantly improved antioxidant status, sperm quality, and hormonal level concerning the HFD/STZ untreated group. Moreover, treatment with H. indicum restored the altered testicular histology and histomorphometric parameters. This study showed that H. indicum markedly improves male reproductive parameters in diabetic rats, and could therefore be a promising alternative therapy in combating male reproductive disorders associated with diabetes.

Graphical Abstract