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Purpose <p>To determine the effects of curcumin supplementation on inflammatory and oxidative stress biomarkers following strenuous exercise.</p> Methods <p>In a double-blinded, randomised, between-subjects design, 26 healthy males and females (mean ± SD: age: 25 ± 6 years, height: 171 ± 8&#xa0;cm, weight: 69 ± 11&#xa0;kg) consumed either 1000&#xa0;mg/day of curcumin or a placebo for 4 days before completing 100 drop jumps and 50 squat jumps. Blood and urine samples were collected at pre-, post-, 1-, and 2-hour post-exercise to assess inflammatory (total and differential leukocyte concentrations, platelets, interleukin (IL)-6, IL-10, tumour necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP-1), granulocyte colony-stimulating factor (G-CSF), vascular cell adhesion molecule-1 (VCAM-1)), and oxidative stress (glutathione peroxidase (GPX), 8-hydroxydeoxyguanosine (8-OHdG)) biomarkers. Curcumin metabolites (curcumin glucuronide, curcumin sufhate, bidemethoxycurcumin, and demethoxycurcumin) were measured pre-exercise to 1-hour post-exercise.</p> Results <p>Curcumin supplementation increased total plasma metabolites at all time-points (<i>P</i> &lt; 0.05); the greatest mean increases were in curcumin glucuronide, which peaked 1-hour post-exercise (curcumin 211.7 ± 461.9 vs. placebo 1.1 ± 0.4 nM). Total leukocyte counts were lower in the curcumin condition at all time-points (supplement effect <i>p</i> &lt; 0.05). Neutrophils were lower after curcumin 2-hours post-exercise (curcumin; 4.1 ± 1.5 vs. placebo: 5.8 ± 2.1 10<sub>9</sub> cells/L; <i>p</i> &lt; 0.001). Plasma VCAM-1, G-CSF and urinary 8-OHdG were higher in the curcumin condition at all time-points (supplement effect; <i>p</i> &lt; 0.05). There were no between group differences for any other biomarkers (<i>p</i> &gt; 0.05).</p> Conclusions <p>Curcumin supplementation increased circulating metabolites but had limited effects on markers of inflammation and oxidative stress after strenuous exercise, showing no clear pattern of change to suggest anti-inflammatory or antioxidant effects.</p> Pre-registration <p>https://osf.io/3k6yp/.</p>

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The effects of acute curcumin supplementation on markers of inflammation and oxidative stress after strenuous exercise

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月18日

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  • Abrar Alhebshi,
  • Josh Thorley,
  • Ana Rodriguez-Mateos,
  • Zicheng Zhang,
  • Lewis J. James,
  • Tom Clifford

摘要

Purpose

To determine the effects of curcumin supplementation on inflammatory and oxidative stress biomarkers following strenuous exercise.

Methods

In a double-blinded, randomised, between-subjects design, 26 healthy males and females (mean ± SD: age: 25 ± 6 years, height: 171 ± 8 cm, weight: 69 ± 11 kg) consumed either 1000 mg/day of curcumin or a placebo for 4 days before completing 100 drop jumps and 50 squat jumps. Blood and urine samples were collected at pre-, post-, 1-, and 2-hour post-exercise to assess inflammatory (total and differential leukocyte concentrations, platelets, interleukin (IL)-6, IL-10, tumour necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP-1), granulocyte colony-stimulating factor (G-CSF), vascular cell adhesion molecule-1 (VCAM-1)), and oxidative stress (glutathione peroxidase (GPX), 8-hydroxydeoxyguanosine (8-OHdG)) biomarkers. Curcumin metabolites (curcumin glucuronide, curcumin sufhate, bidemethoxycurcumin, and demethoxycurcumin) were measured pre-exercise to 1-hour post-exercise.

Results

Curcumin supplementation increased total plasma metabolites at all time-points (P < 0.05); the greatest mean increases were in curcumin glucuronide, which peaked 1-hour post-exercise (curcumin 211.7 ± 461.9 vs. placebo 1.1 ± 0.4 nM). Total leukocyte counts were lower in the curcumin condition at all time-points (supplement effect p < 0.05). Neutrophils were lower after curcumin 2-hours post-exercise (curcumin; 4.1 ± 1.5 vs. placebo: 5.8 ± 2.1 109 cells/L; p < 0.001). Plasma VCAM-1, G-CSF and urinary 8-OHdG were higher in the curcumin condition at all time-points (supplement effect; p < 0.05). There were no between group differences for any other biomarkers (p > 0.05).

Conclusions

Curcumin supplementation increased circulating metabolites but had limited effects on markers of inflammation and oxidative stress after strenuous exercise, showing no clear pattern of change to suggest anti-inflammatory or antioxidant effects.

Pre-registration

https://osf.io/3k6yp/.