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Background <p>Pneumonia remains a major cause of morbidity and mortality worldwide, and right ventricular dysfunction may contribute to adverse clinical outcomes. Right ventricular global longitudinal strain (RVGLS) is an emerging echocardiographic marker for assessing right ventricular function, but its prognostic and clinical utility in pneumonia has not been fully clarified.</p> Methods <p>Eighty patients hospitalized with pneumonia underwent echocardiographic assessment, including RVGLS measurement via 2D speckle tracking echocardiography. Patients were categorized into two groups: reduced RVGLS (absolute value &lt; 20%) and normal RVGLS (absolute value ≥ 20%). Demographic, clinical, laboratory, and echocardiographic data were compared, and associations with in-hospital outcomes were analyzed.</p> Results <p>Twenty-eight patients (35%) had reduced RVGLS. Compared with the normal RVGLS group, patients with reduced RVGLS had significantly higher N-terminal pro–brain natriuretic peptide and troponin levels. Echocardiographically, patients with reduced RVGLS demonstrated lower tricuspid annular plane systolic excursion and right ventricular ejection fraction, higher pulmonary artery pressures, and larger right ventricular and pulmonary artery diameters, although most diameter measurements remained within reference value thresholds (all <i>P</i> &lt; 0.05). Prolonged hospitalization &gt; 7&#xa0;days (50.0% vs. 28.8%, <i>P</i> = 0.044) and &gt; 10&#xa0;days (21.4% vs. 5.8%, <i>P</i> = 0.029), as well as longer duration of oxygen therapy (4.30&#xa0;days vs. 2.60&#xa0;days, <i>P</i> = 0.043), were significantly more common in the reduced RVGLS group. Intensive care unit admission and short-term mortality did not differ significantly between groups.</p> Conclusions <p>Reduced RVGLS in pneumonia patients is associated with markers of disease severity, longer hospital stays, and extended oxygen therapy requirements, even without overt right ventricular failure. RVGLS assessment may assist in identifying patients at risk for a complicated clinical course.</p> Graphical Abstract <p></p>

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Clinical associations of right ventricular strain in community-acquired pneumonia: a prospective cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月1日

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  • Eren Ozan Bakir,
  • Mutlu Onur Gucsav,
  • Ahmet Anil Baskurt

摘要

Background

Pneumonia remains a major cause of morbidity and mortality worldwide, and right ventricular dysfunction may contribute to adverse clinical outcomes. Right ventricular global longitudinal strain (RVGLS) is an emerging echocardiographic marker for assessing right ventricular function, but its prognostic and clinical utility in pneumonia has not been fully clarified.

Methods

Eighty patients hospitalized with pneumonia underwent echocardiographic assessment, including RVGLS measurement via 2D speckle tracking echocardiography. Patients were categorized into two groups: reduced RVGLS (absolute value < 20%) and normal RVGLS (absolute value ≥ 20%). Demographic, clinical, laboratory, and echocardiographic data were compared, and associations with in-hospital outcomes were analyzed.

Results

Twenty-eight patients (35%) had reduced RVGLS. Compared with the normal RVGLS group, patients with reduced RVGLS had significantly higher N-terminal pro–brain natriuretic peptide and troponin levels. Echocardiographically, patients with reduced RVGLS demonstrated lower tricuspid annular plane systolic excursion and right ventricular ejection fraction, higher pulmonary artery pressures, and larger right ventricular and pulmonary artery diameters, although most diameter measurements remained within reference value thresholds (all P < 0.05). Prolonged hospitalization > 7 days (50.0% vs. 28.8%, P = 0.044) and > 10 days (21.4% vs. 5.8%, P = 0.029), as well as longer duration of oxygen therapy (4.30 days vs. 2.60 days, P = 0.043), were significantly more common in the reduced RVGLS group. Intensive care unit admission and short-term mortality did not differ significantly between groups.

Conclusions

Reduced RVGLS in pneumonia patients is associated with markers of disease severity, longer hospital stays, and extended oxygen therapy requirements, even without overt right ventricular failure. RVGLS assessment may assist in identifying patients at risk for a complicated clinical course.

Graphical Abstract