<p>Omics technologies such as genomics, transcriptomics, proteomics, metabolomics, Lipidomes and nutrigenomics are revolutionising aquaculture by giving a deeper understanding of biological systems at the molecular level. Fish nutrigenomics is an emerging area of research that focuses on the relationship between nutrition and gene expression in fish species to optimise growth, health, and sustainability in aquaculture systems. Nutrigenomics helps formulate customised diets leading to efficient feed utilisation, disease resistance, and production of nutritionally enriched fish for human consumption by providing insights into the genetic blueprint of economically important fish species. Additionally, these findings emphasize the impact of advanced genomic tools, including RNA sequencing and CRISPR, in revealing important nutritional pathways and genes related to metabolic efficiency and immune response. Moreover, it highlights the scope for nutrigenomics to lower the dependence on the traditional use of fishmeal and fish oil by integrating alternative feed inputs, to reduce the environmental footprint. New findings have opened a new window on sustainable aquaculture and healthy fish products, addressing global food needs and human nutritional supply.</p>