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<p>Hydatid disease, a neglected zoonotic infection caused by <i>Echinococcus granulosus</i>, remains hyperendemic in pastoral regions with limited resources underresourced veterinary surveillance systems. Consequently, deploying point-of-care diagnostic tools for the field surveillance of <i>E. granulosus</i> infection is critical for interrupting transmission chains and curbing echinococcosis dissemination. Here, we developed a rapid fluorescent immunochromatographic test strip using quantum dot (QD) nanobeads as signal reporters and antigen B as the capture probe. Compared with conventional techniques, this novel assay detects <i>E. granulosus</i> antibodies within 15&#xa0;min, significantly reducing the time needed. Furthermore, it exhibits a sensitivity at least an order of magnitude greater than that of conventional colloidal gold-based lateral flow strips. More importantly, the results of our fluorescent immunochromatography test strips were strongly consistent with those of commercial ELISA kits. Owing to its rapid, sensitive, and user-friendly format, this test strip provides a practical point-of-care tool for field-based hydatid disease surveillance and control.</p>

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Quantum dot nanobead-based fluorescent immunochromatography test strips for rapid visual detection of echinococcosis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月19日

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  • Gesang Zhuoma,
  • Gongsang Quzhen,
  • Bianba Yangla,
  • Geshang Yangzong,
  • Chidan Zhuoga,
  • Yuzhen Deji,
  • Suolang Sizhu

摘要

Hydatid disease, a neglected zoonotic infection caused by Echinococcus granulosus, remains hyperendemic in pastoral regions with limited resources underresourced veterinary surveillance systems. Consequently, deploying point-of-care diagnostic tools for the field surveillance of E. granulosus infection is critical for interrupting transmission chains and curbing echinococcosis dissemination. Here, we developed a rapid fluorescent immunochromatographic test strip using quantum dot (QD) nanobeads as signal reporters and antigen B as the capture probe. Compared with conventional techniques, this novel assay detects E. granulosus antibodies within 15 min, significantly reducing the time needed. Furthermore, it exhibits a sensitivity at least an order of magnitude greater than that of conventional colloidal gold-based lateral flow strips. More importantly, the results of our fluorescent immunochromatography test strips were strongly consistent with those of commercial ELISA kits. Owing to its rapid, sensitive, and user-friendly format, this test strip provides a practical point-of-care tool for field-based hydatid disease surveillance and control.