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Background <p>Biological aging may influence long-term outcomes following liver transplantation (LT), yet longitudinal epigenetic changes in transplant recipients remain poorly characterized.</p> Methods <p>Peripheral blood mononuclear cells (PBMCs) from LT recipients were analyzed using Infinium Methylation EPIC v2.0 arrays at transplantation (T0), five years (T5), and ten years (T10) post-transplant. Differentially methylated regions (DMRs) and epigenetic age acceleration were evaluated.</p> Results <p>The largest epigenetic changes occurred between five and ten years post-transplant, with 211 DMRs enriched in immune-related pathways. However, epigenetic clock analyses showed no significant differences in biological age acceleration.</p> Conclusions <p>Long-term LT survival is associated with immune-related epigenetic remodeling rather than global biological aging acceleration.</p>

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Epigenome-wide association study uncovers aging-related genes and enriched pathways in liver transplant recipients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月20日

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  • Cristina Baciu,
  • Bima J. Hasjim,
  • Elisa Pasini,
  • Giovanna Saracino,
  • Sumeet K. Asrani,
  • Mamatha Bhat

摘要

Background

Biological aging may influence long-term outcomes following liver transplantation (LT), yet longitudinal epigenetic changes in transplant recipients remain poorly characterized.

Methods

Peripheral blood mononuclear cells (PBMCs) from LT recipients were analyzed using Infinium Methylation EPIC v2.0 arrays at transplantation (T0), five years (T5), and ten years (T10) post-transplant. Differentially methylated regions (DMRs) and epigenetic age acceleration were evaluated.

Results

The largest epigenetic changes occurred between five and ten years post-transplant, with 211 DMRs enriched in immune-related pathways. However, epigenetic clock analyses showed no significant differences in biological age acceleration.

Conclusions

Long-term LT survival is associated with immune-related epigenetic remodeling rather than global biological aging acceleration.