Scholarlink

Background <p>CBX7, a member of the Chromobox protein family and a core subunit of Polycomb Repressive Complex 1 (PRC1), has recently gained attention as an important regulator of chromatin organization and gene expression. In tumorigenesis, CBX7 can act as an oncogene or tumor suppressor highlighting a complex role to be investigated.</p> Main body <p>In glioblastoma multiforme (GBM), CBX7 acts primarily as a tumor suppressor. Reduced CBX7 activity is related to poor patient survival by inducing glioblastoma cell hyperproliferation and invasiveness. Several molecular studies have highlighted the direct involvement of CBX7 in fundamental processes such as cell cycle regulation and the maintenance of stem-like characteristics. In GBM, epigenetic phenomena (such as hypermethylation of the CBX7 promoter region), regulation mediated by specific miRNAs, and protein-protein interactions are responsible for CBX7 downregulation.</p> Conclusion <p>Restoring CBX7 expression in GBM reduced cell invasiveness and migration, highlighting its importance as a prognostic indicator and potential therapeutic target. Overall, current data support a model in which CBX7 operates as a crucial epigenetic regulator in glioblastoma, and its modulation may offer new opportunities for the development of targeted treatment strategies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Epigenetic regulation by CBX7 in glioblastoma: molecular mechanisms and translational perspectives

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月29日

查看全文
  • Fatima Fayyaz,
  • Gregorio Favale,
  • Lucia Capasso,
  • Rosaria Casalino,
  • Donato Mele,
  • Giulia Verrilli,
  • Mariarosaria Conte,
  • Vincenzo Carafa,
  • Angela Nebbioso,
  • Lucia Altucci

摘要

Background

CBX7, a member of the Chromobox protein family and a core subunit of Polycomb Repressive Complex 1 (PRC1), has recently gained attention as an important regulator of chromatin organization and gene expression. In tumorigenesis, CBX7 can act as an oncogene or tumor suppressor highlighting a complex role to be investigated.

Main body

In glioblastoma multiforme (GBM), CBX7 acts primarily as a tumor suppressor. Reduced CBX7 activity is related to poor patient survival by inducing glioblastoma cell hyperproliferation and invasiveness. Several molecular studies have highlighted the direct involvement of CBX7 in fundamental processes such as cell cycle regulation and the maintenance of stem-like characteristics. In GBM, epigenetic phenomena (such as hypermethylation of the CBX7 promoter region), regulation mediated by specific miRNAs, and protein-protein interactions are responsible for CBX7 downregulation.

Conclusion

Restoring CBX7 expression in GBM reduced cell invasiveness and migration, highlighting its importance as a prognostic indicator and potential therapeutic target. Overall, current data support a model in which CBX7 operates as a crucial epigenetic regulator in glioblastoma, and its modulation may offer new opportunities for the development of targeted treatment strategies.