<p>During the long-term service periods of Prestressed Concrete(PC) continuous girder bridges, structural time-varying reliability will degrade due to cyclic creep induced by dynamic vehicle loading, which increases the risk of structural failure. This paper provided a time-varying reliability prediction method for the prestressed concrete continuous T-girder bridge considering random vehicle load information and cyclic creep information. Firstly, the random vehicle load information is simulated with Monte Carlo random simulation method and MATLAB software based on the monitored data obtained from weigh-in-motion (WIM) system. Then, the concrete shrinkage strain model, concrete static creep strain model, concrete cyclic creep strain model and the overall strain model are respectively provided by combining the CEB-FIP model with concrete cyclic creep theory. Finally, by using a numerical model of prestressed concrete bridge, a time-variant reliability analyzing approach of prestressed concrete T-girder bridge considering the limit state of load carrying capacity and the limit state of serviceability is investigated in detail by integrating the random vehicle loading information with the concrete cyclic creep information.</p>