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Background <p>Studies suggest that obesity may exacerbate the clinical symptoms of chronic obstructive pulmonary disease (COPD), and early screening is critical for improving treatment outcomes. This study aims to investigate the correlation between a novel metabolic indicator, the Body Roundness Index (BRI), and the risk of COPD.</p> Methods <p>Utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2003–2016, we employed multivariate logistic regression models to assess the association between BRI and COPD. Stratified subgroup analyses, smooth curve fitting, and threshold effect analyses were conducted for further exploration.</p> Results <p>Among 35,356 participants included in the study, 3,018 were diagnosed with COPD. Logistic regression revealed that elevated BRI levels were significantly associated with an increased risk of COPD after adjusting for confounding factors (<i>P</i>-value &lt; 0.001). Subgroup analyses indicated that this association was more pronounced in Mexican Americans, individuals with education beyond high school, and those with diabetes (<i>P</i>-value &lt; 0.05). Smooth curve fitting identified a threshold effect for BRI, with a significant inflection point at 4.57 (<i>P</i> = 0.048) based on threshold effect analysis.</p> Conclusion <p>This study suggests that BRI is associated with COPD risk and may serve as a potential predictor, though causality cannot be inferred due to the cross-sectional design. Longitudinal studies are warranted to confirm this relationship.</p>

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Association between body roundness index and chronic obstructive pulmonary disease: a cross-sectional analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月6日

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  • Shaofeng Zhang,
  • Jiayi Liu,
  • Lichang Chen,
  • Xiang Liu,
  • Yidan Lin,
  • Jia Jiang,
  • Yaling Zeng,
  • Jia Li,
  • Chunyan Lin,
  • Xinyu Song,
  • Qiang Xiao

摘要

Background

Studies suggest that obesity may exacerbate the clinical symptoms of chronic obstructive pulmonary disease (COPD), and early screening is critical for improving treatment outcomes. This study aims to investigate the correlation between a novel metabolic indicator, the Body Roundness Index (BRI), and the risk of COPD.

Methods

Utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2003–2016, we employed multivariate logistic regression models to assess the association between BRI and COPD. Stratified subgroup analyses, smooth curve fitting, and threshold effect analyses were conducted for further exploration.

Results

Among 35,356 participants included in the study, 3,018 were diagnosed with COPD. Logistic regression revealed that elevated BRI levels were significantly associated with an increased risk of COPD after adjusting for confounding factors (P-value < 0.001). Subgroup analyses indicated that this association was more pronounced in Mexican Americans, individuals with education beyond high school, and those with diabetes (P-value < 0.05). Smooth curve fitting identified a threshold effect for BRI, with a significant inflection point at 4.57 (P = 0.048) based on threshold effect analysis.

Conclusion

This study suggests that BRI is associated with COPD risk and may serve as a potential predictor, though causality cannot be inferred due to the cross-sectional design. Longitudinal studies are warranted to confirm this relationship.