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Background <p>The aim of this study was to investigate the impact of major ozone autohemotherapy on patients with fibromyalgia syndrome experiencing persistent symptoms despite receiving standard medical treatment and implementing lifestyle modifications.</p> Methodology <p>Patients who underwent major ozone autohemotherapy for fibromyalgia syndrome within the last 6 months were included in the study. Patients’ pain levels were assessed using the Visual Analog Scale, the effects of fibromyalgia syndrome on patients were assessed using the Fibromyalgia Impact Questionnaire, and their quality of life was assessed using the 12-Item Short-Form Health Survey before and three months after treatment. Patients’ attitudes toward complementary and alternative medicine were also assessed after treatment using the Holistic Complementary and Alternative Medicine Questionnaire.</p> Results <p>The data’s of 60 patients who had undergone major ozone autohemotherapy for the treatment of fibromyalgia syndrome in the last 6 months were accessed. Fifteen patients with incomplete data and who met the exclusion criteria were excluded, leaving a total of 45 patients for the study. Significant improvements were observed following treatment, with Visual Analog Scale scores decreasing from 8 (IQR = 1.0) to 4 (IQR = 3.0) (<i>p</i> &lt; 0.001), Fibromyalgia Impact Questionnaire scores decreasing from 65.72 ± 10.50 to 40.91 ± 18.02 (<i>p</i> &lt; 0.001, (95% CI 19.9 to 29.8)), 12-Item Short-Form Health Survey Physical Component Summary scores increasing from 28.0 (IQR = 13.04) to 44.3 (IQR = 13.04) (<i>p</i> &lt; 0.001), and Mental Component Summary scores increasing from 33.3 (IQR = 9.97) to 43.2 (IQR = 18.78) (<i>p</i> &lt; 0.001). The study found several significant correlations between clinical outcomes and patient characteristics. Higher Holistic Complementary and Alternative Medicine Questionnaire scores were negatively associated with improvements in Visual Analog Scale, Fibromyalgia Impact Questionnaire, and 12-Item Short-Form Health Survey Physical and Mental Component Summary. Notably, reductions in Visual Analog Scale and Fibromyalgia Impact Questionnaire scores were strongly correlated (<i>r</i> = 0.817, <i>p</i> &lt; 0.001), indicating parallel improvement in pain and function.</p> Conclusion <p>Major ozone autohemotherapy has the potential to enhance Visual Analog Scale, Fibromyalgia Impact Questionnaire, and 12-Item Short-Form Health Survey outcomes in patients with fibromyalgia syndrome. These results need to be validated with prospective studies including a control group.</p>

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Effects of major ozone autohemotherapy on fibromyalgia: a retrospective clinical study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月19日

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  • Selda Çiftci İnceoğlu,
  • Aylin Ayyıldız,
  • Muhammed Fatih Erden,
  • Meryem Aşık,
  • Alperen İnceoğlu,
  • Banu Kuran

摘要

Background

The aim of this study was to investigate the impact of major ozone autohemotherapy on patients with fibromyalgia syndrome experiencing persistent symptoms despite receiving standard medical treatment and implementing lifestyle modifications.

Methodology

Patients who underwent major ozone autohemotherapy for fibromyalgia syndrome within the last 6 months were included in the study. Patients’ pain levels were assessed using the Visual Analog Scale, the effects of fibromyalgia syndrome on patients were assessed using the Fibromyalgia Impact Questionnaire, and their quality of life was assessed using the 12-Item Short-Form Health Survey before and three months after treatment. Patients’ attitudes toward complementary and alternative medicine were also assessed after treatment using the Holistic Complementary and Alternative Medicine Questionnaire.

Results

The data’s of 60 patients who had undergone major ozone autohemotherapy for the treatment of fibromyalgia syndrome in the last 6 months were accessed. Fifteen patients with incomplete data and who met the exclusion criteria were excluded, leaving a total of 45 patients for the study. Significant improvements were observed following treatment, with Visual Analog Scale scores decreasing from 8 (IQR = 1.0) to 4 (IQR = 3.0) (p < 0.001), Fibromyalgia Impact Questionnaire scores decreasing from 65.72 ± 10.50 to 40.91 ± 18.02 (p < 0.001, (95% CI 19.9 to 29.8)), 12-Item Short-Form Health Survey Physical Component Summary scores increasing from 28.0 (IQR = 13.04) to 44.3 (IQR = 13.04) (p < 0.001), and Mental Component Summary scores increasing from 33.3 (IQR = 9.97) to 43.2 (IQR = 18.78) (p < 0.001). The study found several significant correlations between clinical outcomes and patient characteristics. Higher Holistic Complementary and Alternative Medicine Questionnaire scores were negatively associated with improvements in Visual Analog Scale, Fibromyalgia Impact Questionnaire, and 12-Item Short-Form Health Survey Physical and Mental Component Summary. Notably, reductions in Visual Analog Scale and Fibromyalgia Impact Questionnaire scores were strongly correlated (r = 0.817, p < 0.001), indicating parallel improvement in pain and function.

Conclusion

Major ozone autohemotherapy has the potential to enhance Visual Analog Scale, Fibromyalgia Impact Questionnaire, and 12-Item Short-Form Health Survey outcomes in patients with fibromyalgia syndrome. These results need to be validated with prospective studies including a control group.